- Kinase definition, a transferase that catalyzes the phosphorylation of a substrate by ATP. See more. — “Kinase | Define Kinase at ”,
- Kinase Manufacturers & Kinase Suppliers Directory - Find a Kinase Manufacturer and Supplier. Choose quality Kinase Manufacturers, Suppliers, Exporters at . — “Kinase-Kinase Manufacturers, Suppliers and Exporters on”,
- The catalytic subunits of protein kinases are highly conserved, and several structures have been solved , leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases  mitogen-activated protein kinase (MAPK)activation pathways are. — “IPR003527 MAP kinase, conserved site”,
- By providing a fast, accurate, uniform and quantitative kinase profile that details how well each compound binds to both intended and unintended targets, KINOMEscan™ transforms the promiscuity of kinase inhibitors into a discovery advantage. The KINOMEscan™ Advantage. — “KINOMEscan™ Kinase Selectivity & Screening Services”,
- Information on EC 184.108.40.206 - uridine kinase recombinant uridine kinase 1, 13% of activity with uridine, recombinant uridine kinase 2, 81% of activity with uridine. — “EC 220.127.116.11 - uridine kinase”, brenda-
- Definition of kinase in the Medical Dictionary. kinase explanation. Information about kinase in Free online English dictionary. What is kinase? Meaning of kinase medical term. What does kinase mean?. — “kinase - definition of kinase in the Medical dictionary - by”, medical-
- provides kinase-related products such as protein kinases, kinase inhibitors, activators and substrates as well as antibodies and bioluminescent luciferase assays and ATP determination kits for research and development. — “ Shop - Your favourite supplier of kinase”, kinase.us
- kinase (enzyme), an enzyme that adds phosphate groups (PO43−) to other molecules. A large number of kinases exist—the human genome contains at least 500 kinase-encoding genes. Included among these enzymes' targets for phosphate group addition. — “kinase (enzyme) -- Britannica Online Encyclopedia”,
- Kinase Assays. — “Kinase Assays - Biocompare Buyer's Guide For Life Scientists”,
- In chemistry and biochemistry, a kinase , alternatively known as a phosphotransferase , is a type of enzyme that transfers phosphate groups from high-energy donor molecules, such as ATP, to specific substrates. In chemistry and biochemistry, a kinase , alternatively known as a phosphotransferase ,. — “Kinase”,
- The world's first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. In contrast, C kinase inhibition actually potentiates the initial growth response to L1 or N-cadherin . — “WikiGenes - CSNK1A1 - casein kinase 1, alpha 1”,
- kinase ( ) n. Any of various enzymes that catalyze the transfer of a phosphate group from a donor, such as ADP or ATP, to an acceptor. — “kinase: Definition from ”,
- The Kinase Knowledgebase (KKB) is Eidogen-Sertanty's database of kinase structure-activity and chemical synthesis data. — “”
- kinase sentence examples. Using protein chips ( glass slides to which fragments of proteins are fixed ), the team showed which kinase activate d which protein. The gene family encoding protein kinases is the most commonly mutated in human cancer. — “Use kinase in a sentence | kinase sentence examples”,
- Kinase Abstracts: Rho-associated kinase (Rho-kinase/ROCK/ROK) is a serine/threonine kinase and plays an important role in various cellular functions. The cAMP-dependent protein kinase (protein kinase A/PKA) and protein kinase C (PKC) are also. — “Kinase: Health Information from Peer Reviewed Scientific”, level1
- The Kinase-Glo® Luminescent Kinase Assays are homogeneous non-radioactive methods for determining the activity of purified kinases by quantifying the amount of ATP remaining in solution The assay procedure involves addition of a single reagent directly to a completed kinase reaction. — “Kinase-Glo Luminescent Kinase Assays”,
- Pharma labs typically only use P33 radiolabeled kinase assay profiling for only a few select compounds. Now, RBC's proprietary nanoliter screening techniques make this gold standard kinase assay format available for large-scale profiling and HTS. — “Reaction Biology Kinase Assays”,
- Phospho-p70 S6 Kinase (Ser371) Antibody detects endogenous levels of p70 S6 kinase only when phosphorylated at serine 371. This antibody also detects p85 S6 kinase when phosphorylated at the ***ogous site (Ser394) and possibly S6KII beta phosphorylated at Ser370. Source / Purification. — “Phospho-p70 S6 Kinase (Ser371) Antibody #9208”,
- pathways, whether protein kinase C (PKC) activity plays a crucial role remains as yet unclear. ent Ser/Thr protein kinase called an integrin-linked kinase (ILK) is a potential PDK2, as it is capable of. — “PII: S0898-6568(02)00047-5”, kinase.uhnres.utoronto.ca
- A resource on protein kinases, a key class of regulatory proteins. Includes genomic and evolutionary ***yses (kinomes), classification, disease associationa and an extensive database of protein kinase genes. — “”,
- In chemistry and biochemistry, a kinase, alternatively known as a phosphotransferase, is a type of enzyme that transfers phosphate groups from high-energy donor molecules, such as ATP, to specific substrates. One of the largest groups of kinases are protein kinases, which act on and modify the. — “Kinase - Wikipedia, the free encyclopedia”,
- Definition of kinase in the Online Dictionary. Meaning of kinase. Pronunciation of kinase. Translations of kinase. kinase synonyms, kinase antonyms. Information about kinase in the free online English dictionary and encyclopedia. creatine kinase. — “kinase - definition of kinase by the Free Online Dictionary”,
related videos for kinase
- Invitrogen LanthaScreen® Eu Kinase Binding Assay Capabilities Video The LanthaScreen® Eu Kinase Binding Assay is a simple, easy-to-optimize kinase assay for screening and multiple downstream applications. In this video, you will learn the assay principle and see several data examples for the applications enabled by this assay format. Applications include but arent limited to: assay development for difficult kinases (including non-activated, low purity kinases or those without a known substrate); measuring on-off rates, and evaluating allosteric inhibitors.
- Molecular Clues Help Refine Kinase Inhibitor Strategy for GI Robert G. Maki, MD, Ph.D., Memorial Sloan-Kettering Cancer Center ORLANDO -- In the post-imatinib (Gleevec) era, treatment of gastrointestinal stromal tumors has shifted from serial surgeries to refinement of kinase inhibitor dosing, according to this presentation from the ASCO-GI symposium here.
- Protein kinase C
- Molecular mechanism of E. Coli Multidrug tolerance mediated by HipA protein kinase rev E. Coli and other bacteria may go dormant allowing then to evade drugs. The Mechanisms that allow dormancy are modulated by HipA protein. HipB neutralizes HipA by latching onto it and locking it into a shape that prevents it for shutting down the protein production.
- The molecular force sensor titin kinase Our muscles get stronger after excercise, but how do they sense where and when to grow? In combination with AFM-based single molecule force spectroscopy, molecular dynamics simulations and enzymatics we showed, that the autoinhibited muscle enzyme titin kinase gets activated by physiological forces and can act as a force sensor regulating gene expression and protein turnover. - The 3D animation shows a zoom inside the muscle up to the smales protein building blocks to visualize how contraction is generated by myosin and actin filaments. In their center, these motor strand are connected and aligned through the elastic titin-network, which contains the molecular force sensor titin kinase. Force imbalances distort the elastic titin-network and open the binding pocked of titin kinase, which is now primed for docking of the cosubstrate ATP. This part of the animation shows molecular dynamics simulations performed at atomic resolution. Through the force-induced binding of ATP, titin kinase gets activated like a mechanical fuse and marks other reporter molecules with parts of ATP. The initiated signaling cascade regulates muscle gene expression and protein turnover. - Further Information: - www.biophysik.physik.uni- - publication: -
- The JIL-1 kinase regulates the structure of Drosophila polytene chromosomes From the Springer article: The JIL-1 kinase regulates the structure of Drosophila polytene chromosomes by: Deng, Huai; Zhang, Weiguo; Bao, Xiaomin; Martin, Janine N.; Girton, Jack; Johansen, Jørgen; Johansen, Kristen M.; Quicktime Movie (4769 kb) Journal: Chromosoma Vol. 114 Issue 3 DOI: 10.1007/s00412-005-0006-8 Published: 2005-08-01
- A 3-D model of human Ahsg, a natural inhibitor of the insulin receptor tyrosine kinase he polypeptide chain is colored from N-terminus (blue) to C-terminus (red) in rainbow. The white residues are thought to be the amino acid side chains which engage the extracellular segment of the beta-subunit. The key serine residue (Ser330 or Ser312) is highlighted in green. The green helical bundle on the right is the core of the cystatin domain D2. The blue helical bundle on the upper left is the core of the cystatin domain D1, posited to be involved in control of biomineralization, recognizing some special form of calcium phosphate like octacalcium phosphate or some intermediate on the path to true hydroxyapatite.
- Human CK-MB ELISA Kit, CREATINE KINASE (CK-MB) ENZYME IMMUNOASSAY TEST KIT Cardiac Markers Elisa kits - Cardiac Markers Elisa assays: ELISA Test KIt for Quantitative Measurement of Creatine-Kinase (CK-MB), Human CK-MB ELISA Test Kit. ELISA kits manufacturer - ElLISA assays supplier: Diagnostic Automation/Cortez Diagnostics, Inc., Tel: 818-591 3030, USA
- BAOSearch example #1: Explore kinase and biochemical concepts BAOSearch demonstration example using concept search terms: "kinase" AND "biochemical", filtering for percent inhibition and IC50. baosearch.ccs.miami.edu
- Targeting the Phosphoinositide-3 Kinase (PI3K) Pathway in Breast Cancer Lecture by José Baselga, MD This podcast reviews current data related to the phosphoinositide-3 kinase (PI3K) pathway, its role in breast cancer, the frequently with which PI3K is aberrant in breast cancer, and the potential clinical implications of using agents that target the PI3K pathway.
- The MET Receptor Tyrosine Kinase and Autism Risk Rapid progress is being made on a number of fronts with regard to understanding the etiologies that underlie the autisms. The autisms are among the most common of neurodevelopmental disorders, and are highly heterogeneous in disorder phenotype, longitudinal trajectory of symptoms and response to treatment. A brief overview of the current state of thinking regarding the genetic and environmental risk factors will be discussed. Work from Dr. Levitts laboratory will be the focus of the remainder of the lecture. Series: MIND Institute Lecture Series on Neurodevelopmental Disorders [7/2009] [Health and Medicine] [Professional Medical Education] [Show ID: 16238]
- Receptor tyrosine kinase signaling The above video is reposted from the University of California -- Berkeley's Webcast.Berkeley. The original version can be found here webcast.berkeley.edu This video is released under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License.
- MAP Kinase.mp4
- MAP Kinase The mitogen activated protein kinase pathway (MAP kinase pathway) is a key signaling pathway by which the cell responds to external stimuli. This video describes this pathway. This video is from: Janeway's Immunobiology, 7th Edition Murphy, Travers, & Walport ISBN: 978-0-8153-4123-9
- The MAP-Kinase (MAPK) signalling pathway
- A fat kid laughing at a friend on kinase The title
- Lecture 4 Manrose Singh - Solid Phase Peptide Synthesis and its Role in Understanding Nek2 Kinase Lecture #4 at Rockefeller University: HCS student, Manrose Singh, presents his PowerPoint on Solid Phase Peptide Synthesis and its Role in Understanding Nek2 Kinase. Harlem Children Society (HCS: www.hcs2) a Not-for-profit organization founded on June 5, 2000, by Dr. Sat Bhattacharya, selects promising students from communities ridden by poverty and adverse situations, engaging and training them in one-on-one mentoring and hands-on research in STEM and allied sciences. The US HCS Class of 2010 consists of 300 young scholars from over 200 schools from diverse ethnicities (40% African American, 26% Hispanic, 16% Native American, 14% Asian, and 4% Caucasian). They are mentored by over 1500 mentors -- all leading scientists, engineers, doctors and other professionals from over 250 institutions. All HCS students graduating high school students were admitted to college/university, with 20% attending Ivy League schools. "HCS Global Science Parades and Science Street Fairs & Festivals", organized in the Fall each year are the jewels in the crown of the HCS program, culminating in a series of simultaneous worldwide, global webcasted events, where students present their hands-on research projects. The event celebrates the unifying impact of academic inquiry and the human spirit across continental and cultural divides.
- CREATINE KINASE Ion - Radical mechanism of Phosphorylation ADP to ATP MAGNETIC ISOTOP EFFECT Mg 25 CREATINE KINASE Active site Ion - Radical mechanism of Phosphorylation ADP to ATP with CREATINEPHOSPHATE as a donor of phosphate groop. ISOTOP Mg 25 Special thanks for Julia Belokrinitskaya
- Activation of Protein Kinase A by cAMP Cyclic AMP activates protein kinase A by binding to a regulatory peptide and altering its conformation. Learn more in this molmodac, or molecular mode of action, video.
- Herpes Simplex Virus Type 1 Thymidine Kinase Interacting With (North)-Methanocarba- Thymidine
- Oncogenic activation receptor tyrosine kinases
- Pat Neal, RN with Ginger Sawyer and Carol Gangstead Side effects of Tyrosine Kinase Inhibitors Intro
- SIGNAL TRANSDUCTION BY THE TYROSINE KINASE PATHWAY IS INVOLV 9th.World Comgress of the Intenational Hepato-Pancreato-Biliary Association-IHPBA-2010 - Buenos Aires Argentina -LIVER- DVD 10 Mini Oral -HCC-
- CDK2 - Cyclin Dependant Kinases. Request: Benefited Users can pray for, well-being of my friend Hemamani Deepa.
- The Ras-MAP kinase pathway The above video is reposted from the University of California -- Berkeley's Webcast.Berkeley. The original version can be found here webcast.berkeley.edu This video is released under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License.
- Philip Cohen - Part 7 - Kinases as Cancer and other Drug Targets Prof. Sir Philip Cohen delivers an engaging and informative talk about the targeting of phosphate pathway as the cure for cancer and other diseases. In this clip Philip explains if drugs that disrupt phosphorylation will bring ne treatments not just for different forms of cancer but for other diseases. This was a British Science Association Tayside and Fife branch lecture, as part of Dundee Science Festival presented on 28th October 2010.
- Invitrogen Procedure 1: User Instructional Video for the LanthaScreen® Eu Kinase Binding Assay The LanthaScreen® Eu Kinase Binding Assay is a simple, easy-to-optimize kinase assay for screening and multiple downstream applications. This video series is split into two procedures. In this procedure, we will walk you through the simple assay protocol and demonstrate how to optimize tracer concentrations and set up tracer titration experiments. Youll also get information for instrument compatibility and how to contact our specialized Technical Support Scientists. To watch us demonstrate how to set up and run compound titration experiments, be sure to view the second procedure video. /bindingassay
- Invitrogen Procedure 2: User Instructional Video for the LanthaScreen® Eu Kinase Binding Assay The LanthaScreen® Eu Kinase Binding Assay is a simple, easy-to-optimize kinase assay for screening and multiple downstream applications. This video series is split into two procedures. This is the second of two procedures, where we will walk you through setting up and running a compound titration experiment. Youll also get information for instrument compatibility and how to contact our specialized Technical Support Scientists. To watch us demonstrate how to optimize tracer concentrations and set up and run compound titration experiments, be sure to view the first procedure video. /bindingassay
- Kinase Plus- Fights fibrin build-up and keeps blood flowing Fibrin, one of the primary clotting agents, should "turn on" in the case of an injury to help clot your blood. Then turn off when the bleeding has stopped. In the elderly and those with chronic health conditions, however, these white stringy fibers develop during the healing process, often forming scar tissue. This excess fibrin—from scars, surgeries, or arterial scl*** plaque (scar tissues of the arteries)—can cause the blood to thicken. The thickened blood acts like a "sludge," preventing oxygen and nutrients from reaching the cells and creating a breeding ground for infectious agents. Thick blood can also be caused by chronic infection, inflammation, and heavy metal toxicity. So keeping your blood—your body's "river of life"—clean and flowing smoothly without infection is vital to staying healthy and feeling better. Research over the past 25 years has shown that Nattokinase—a traditional Japanese folk medicine from Natto—helps strengthen the heart and thin thickened blood by dissolving excess fibrin in the circulatory system. Kinase Plus, a proprietary enzyme blend based on the powerful fibrin-reducing properties of Natto, contains 2000 fibrinolytic units (FU) in each capsule. More potent than other nattokinase supplements, Kinase Plus helps dissolve fibrin build-up to keep your blood flowing freely and smoothly. And because Kinase Plus is so effective, you only need to take up to three capsules a day to feel better—not the six or 12 suggested for other nattokinase ...
- KEA - Kinase Enrichment ***ysis KEA is a tool to compute enrichment of kinase-classes, kinase-families and kinases. This tool was developed at Mount Sinai Medical School, New York at the Ma'ayan Laboratory 11/2008. amp.pharm.mssm.edu
- The JIL-1 kinase regulates the structure of Drosophila polytene chromosomes From the Springer article: The JIL-1 kinase regulates the structure of Drosophila polytene chromosomes by: Deng, Huai; Zhang, Weiguo; Bao, Xiaomin; Martin, Janine N.; Girton, Jack; Johansen, Jørgen; Johansen, Kristen M.; Quicktime Movie (5829 kb) Journal: Chromosoma Vol. 114 Issue 3 DOI: 10.1007/s00412-005-0006-8 Published: 2005-08-01
- Kinase Moves The Audio - Anthrobotic [Live] www.impact89 Kinase Moves The Audio Live in Studio The Basement 8.28.2008
- The JIL-1 kinase regulates the structure of Drosophila polytene chromosomes From the Springer article: The JIL-1 kinase regulates the structure of Drosophila polytene chromosomes by: Deng, Huai; Zhang, Weiguo; Bao, Xiaomin; Martin, Janine N.; Girton, Jack; Johansen, Jørgen; Johansen, Kristen M.; Quicktime Movie (3099 kb) Journal: Chromosoma Vol. 114 Issue 3 DOI: 10.1007/s00412-005-0006-8 Published: 2005-08-01
- CNIO Progress Report (2010,Oct): Interpreting disease associated mutations in human kinases A brief talk intended to be basic and introductory to my on-going research characterizing pathogenic mutations within the human kinome. Protein Kinases are a superfamily of proteins involved in crucial cellular processes such as cell cycle regulation and signal transduction. Accordingly, they play an important role in cancer biology. To contribute to the study of the relation between kinases and disease we compared pathogenic mutations to neutral mutations. First, we ***yzed native and mutant proteins in terms of amino acid composition. Secondly, mutations were characterized according to their potential structural effects and finally, we assessed the location of the different classes of polymorphisms with respect to kinase-relevant positions in terms of subfamily specificity, conservation, accessibility and functional sites. Pathogenic Protein Kinase mutations perturb essential aspects of protein function, including disruption of substrate binding and/or effector recognition at family-specific positions. Interestingly these mutations in Protein Kinases display a tendency to avoid structurally relevant positions, what represents a significant difference with respect to the average distribution of pathogenic mutations in other protein families. Disease associated mutations display sound differences with respect to neutral mutations: several amino acids are specific of each mutation type, different structural properties characterize each class and the distribution of ...
- Glycine Lead of the Protein Kinase A: Another Noble proof of Evolution Protein kinase A is an enzyme that phosphorelates a downstream target peptide. It has a conserved motif called glycine lead where the atp is held during catalysation. The sequence of the glycine lead is GXGXXGXV. The X residues despite being free to be any amino acid remains evolutionarily consistent, the codons coding those residues diversifies in accordance with evolutionary pattern.
- Susan Taylor Part 1: Protein Phosphorylation in Biology In this lecture, I have given an overview of protein kinase structure and function using cyclic AMP dependent kinase (PKA) as a prototype for this enzyme superfamily. I have demonstrated what we have learned from the overall structural kinome which allows us to compare many protein kinases and also to appreciate how the highly regulated eukaryotic protein kinase has evolved. By comparing many protein kinase structures, we are beginning to elucidate general rules of architecture. In addition, I have attempted to illustrate how PKA is regulated by cAMP and how it is localized to specific macromolecular complexes through scaffold proteins.
- Hornopožárský les: Vajíčko: Drosophila maternal nuclear kinase (-) Sb2 Vajíčko: Drosophila maternal nuclear kinase (cca 5C btto): tomash (-), 21.7.2010 (ještě se nepovedlo bez přešahu)
- Early Tyrosine Phosphorylation and the Calcium and Protein Kinase C Mediated Signaling Pathways in T Lymphocytes
- The JIL-1 kinase regulates the structure of Drosophila polytene chromosomes From the Springer article: The JIL-1 kinase regulates the structure of Drosophila polytene chromosomes by: Deng, Huai; Zhang, Weiguo; Bao, Xiaomin; Martin, Janine N.; Girton, Jack; Johansen, Jørgen; Johansen, Kristen M.; Quicktime Movie (7287 kb) Journal: Chromosoma Vol. 114 Issue 3 DOI: 10.1007/s00412-005-0006-8 Published: 2005-08-01
- Novel Kinase Inhibitor Promising in NSCLC Non-small cell lung cancers and other tumors with a mutation in anaplastic lymphoma kinase (ALK) respond dramatically to a novel agent that "switches off" the faulty gene, according to early trial results.
- Susan Taylor Part 2: Architecture of a Protein Kinase In this lecture, I have given an overview of protein kinase structure and function using cyclic AMP dependent kinase (PKA) as a prototype for this enzyme superfamily. I have demonstrated what we have learned from the overall structural kinome which allows us to compare many protein kinases and also to appreciate how the highly regulated eukaryotic protein kinase has evolved. By comparing many protein kinase structures, we are beginning to elucidate general rules of architecture. In addition, I have attempted to illustrate how PKA is regulated by cAMP and how it is localized to specific macromolecular complexes through scaffold proteins.
- Charting Kinase and Phosphatase Inhibitors The Case Center for Proteomics and Bioinformatics presents the following symposium: Series: Understanding Protein Complexes, Networks and the Interactome Title: Charting Kinase and Phosphatase Inhibitors Speaker: Anne Claude Gingras, Ph.D. Investigator, Samuel Lunenfeld Research Institute Date: Monday, October 19, 2009 Session: Morning Session 2 Location: Wolstein Auditorium 1413
Blogs & Forum
blogs and forums about kinase
“ALS TDI forum is a free portal that is dedicated to exchange information about ALS, scientific advances in ALS, and treatments for ALS”
— p38 kinase - ALS Research & Treatments - ALS Forum,
“"LKB1 is a master kinase" What a great subheader in a paper last year by Reuben Shaw (journal link below). Liver kinase B1 (LKB1) first got my attention at the AACR lung cancer meeting in San Diego earlier this year,”
— LKB1 is a master kinase in cancer - Pharma Strategy Blog,
“Also, if you would like to see any particular topic and subject covered, please don't hesitate to email us at contact+blog@. Labels: Cell Signaling, PowerPoint, Signaling Pathways, Src Kinase”
— PowerPoint Tutorials and Blog: Src Kinase Signaling Pathways,
“A Blog all about fitness and bodybuilding supplements like creatine. Creatine Kinase is an enzyme found within the body. The enzyme is expressed by various”
— Creatine Monohydrate " Blog Archive " Creatine Kinase, creatine-
“Forum Guru. Topics: 102. Posts: 588. 03/20/04 - 08:41 AM #1. is it true that when tyrosine kinase is activated it need tyrosine on (tyrosine kinase), Then causes the activation of IRS protein , And after that IRS causes the SH2 to become”
— tyrosin kinase activity, prep4
“Home " Blogs " ruro's blog " Kinase activity profiling. Kinase activity profiling. Submitted by ruro on Wed, 10/14/2009 - 11:04. In of pathway in normal and tumoral cells, indeed in cancer alterations in kinase activity are often reported”
— Kinase activity profiling | RURO,
“Steroids Blog. Steroid Forums. Atypical protein Kinase C alleviates SRC-3 Levels in Breast July 11, 2009 | Posted in Steroids Blog. According to a research published by Cell Press”
— Atypical protein Kinase C alleviates SRC-3 Levels in Breast, e-
“27 known protein tyrosine kinase substrates and their sequence variants. All peptides on the chip contain 8-10 redundancies. Positive controls Recognition and specificity in protein tyrosine kinase-mediated signaling, Trends in Biology Sciences, 20,”
— Application Note – Large Scale Mapping of Kinase Substrate,
“About a year ago we reported of PLoS and Molsoft launching a new way of publishing structural biology related papers. A couple of days ago I've stumbled on one such paper, published in PLoS biology and decided to take the technology for a ride”
— Enhanced paper reading and huge kinase complexes,
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