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  • Clomid Defined Clomid is probably the single most used fertility drug by OBGYNs across the United States. It's a very useful drug--it is overused--but has some good clinical applications. What is Clomid? Clomid is a selective estrogen receptor modulator (SERM) that is in the class of drugs that includes drugs such as tamoxifen which is used in breast cancer. Well, what it does do, it's a drug that looks like estrogen but doesn't function like estrogen. All cells have receptors and that way they can respond to hormonal signals. So there are cells in your pituitary gland which is a gland is up behind your nose. It is responsible for stimulating your ovaries. It secretes another hormone called FSH or follicle stimulating hormone. Now the pituitary starts to secret follicle stimulating hormone and your ovaries start to respond with eggs, and estrogen starts to climb and then the pituitary sees that response. The estrogen binds to receptors on the pituitary and then there's what we call down regulation. And the levels of FSH start to drop. What Clomid does is it binds to the receptor. It sort of is like taking a key that's the same manufacturer as the key to your house but not the right key, so it fits into the lock but it doesn't turn. And so what ends up happening is your pituitary gland is blinded to the response of the ovaries so the pituitary gland continues to secrete FSH. So when you use Clomid you can trick your pituitary gland into making more FSH. Now the ...

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