cisplatin

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Examples
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  • Cisplatin can cause a decrease in the number of blood cells in your bone marrow. Cisplatin can cause a severe form of kidney impairment and hearing loss. — “Cisplatin: MedlinePlus Drug Information”, nlm.nih.gov
  • Platinol (Bristol) Vials containing cisplatin as a lyophilised powder for reconstitution: 10 mg in 20 ml vials and 50 mg in 100 ml vials Vials containing cisplatin as a solution in a concentration of 0.5 mg/ml; 10 mg in 20 ml vial, 25 mg in 50 ml vial and 50 mg in 100 ml vial. — “Cisplatin (PIM 132)”,
  • Cisplatin is a heavy metal that kills cells by interfering with the multiplication of cancer cells. Cisplatin slows or stops the growth and spread of cancer cells in the body. — “Cisplatin”,
  • cisplatin n. A platinum-containing chemotherapeutic drug, Cl 2 H 6 N 2 Pt, used in the treatment of metastatic ovarian or testicular cancers and. — “cisplatin: Definition from ”,
  • A strong and widely used chemotherapy drug, Cisplatin can cause serious side effects. — “Cisplatin”,
  • This page contains brief information about cisplatin and a collection of links to more information about the use of this drug, related news and research results, and ongoing clinical trials. — “Cisplatin - National Cancer Institute”, cancer.gov
  • Hypersensitivity to cisplatin, other platinum-containing compounds, or any component of the formulation (anaphylactic-like reactions have been reported); pre-existing Serum magnesium, as well as other electrolytes, should be monitored both before and within 48 hours after cisplatin therapy. — “Cisplatin: Drug Information Provided by Lexi-Comp: Merck”,
  • Cisplatin is a pharmaceutical chemotherapy drug that is used widely to treat different cancers including testicular, germ cell, head and neck, bladder and lung cancer. Cisplatin belongs to the group of medicines known as alkylating agents. — “Cisplatin medication side effect reduction with natural”,
  • For induction of remissions, a regimen of cisplatin, bleomycin, and vinblastine (with or without other antineoplastic agents) has been used. Regimen consisting of cisplatin and pa***axel is superior to regimen consisting of cisplatin and cyclophosphamide. — “cisplatin : Information on Uses, Dosage & Side Effects on”,
  • Your doctor has ordered the drug cisplatin to help treat your illness. Cisplatin is in a class of drugs known as platinum-containing compounds; it slows or stops the growth of. — “Cisplatin”,
  • Cisplatin symptoms, causes, diagnosis, and treatment information for Cisplatin (Probable human carcinogen - Cisplatin) with alternative diagnoses, full-text book chapters, misdiagnosis, research treatments, prevention, and prognosis. — “Cisplatin - ”,
  • Cisplatin - Cisplatin is an antineoplastic medication. Cisplatin interferes with the growth of cancer cells and slows their growth and spread in the body. - Cisplatin should only be administered under the supervision of a qualified healthcare. — “Cisplatin - Side Effects, Dosage, Interactions - Drugs”,
  • Cisplatin Manufacturers & Cisplatin Suppliers Directory - Find a Cisplatin Manufacturer and Supplier. Choose quality Cisplatin Manufacturers, Suppliers, Exporters at . — “Cisplatin-Cisplatin Manufacturers, Suppliers and Exporters on”,
  • Cisplatin is an anti-cancer (antineoplastic or cytotoxic) chemotherapy drug classified as an alkylating agent. Cisplatin is used to treat testicular, ovarian, bladder, head and neck, esophageal, small and non-small cell lung, breast, cervical,. — “Cisplatin, Platinol AQ, CDDP - Chemotherapy Drugs, Chemo Drug”,
  • Learn about the prescription medication Cisplatin (Cisplatin Injection), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. — “Cisplatin (Cisplatin Injection) Drug Information: User”,
  • Cisplatin. You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. — “Cisplatin - wikidoc”,
  • Definition of cisplatin in the Medical Dictionary. cisplatin explanation. Information about cisplatin in Free online English dictionary. What is cisplatin? Meaning of cisplatin medical term. What does cisplatin mean?. — “cisplatin - definition of cisplatin in the Medical dictionary”, medical-
  • Cisplatin is used to treat testicular, bladder, and ovarian cancers that have spread. — “Cisplatin”,
  • mechanism: Cisplatin induces hypomagnesemia through its renal toxicity possibly by a direct injury to mechanisms of magnesium reabsorption in the ascending limb of the loop of Henle as well as the distal tubule. Consequently, cisplatin increases the urinary loss of magnesium. — “Cisplatin”,
  • Drug information on Platinol (Restricted Access) (cisplatin), includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and what to avoid. — “Platinol (Restricted Access) (cisplatin) Drug Side Effects”,
  • Definition of cisplatin in the Online Dictionary. Meaning of cisplatin. Pronunciation of cisplatin. Translations of cisplatin. cisplatin synonyms, cisplatin antonyms. Information about cisplatin in the free online English dictionary and. — “cisplatin - definition of cisplatin by the Free Online”,
  • Comprehensive and accurate Cisplatin side effects information for consumers and healthcare professionals. — “Cisplatin Side Effects | ”,
  • Cisplatin interferes with the growth of cancer cells and slows their growth and spread in Cisplatin is used to treat various types of cancer including metastatic testicular tumors,. — “Cisplatin - Drugs & Treatments - Revolution Health”,
  • Cisplatin, cisplatinum, or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas, and germ cell tumors. — “Cisplatin - Wikipedia, the free encyclopedia”,

Images
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  • Original Science article Science 2007 318 967 See also under www cipsm de Full View
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  • Figure 2 Representative H E stained histological sections from kidney of A B vehicle treated and C D puromycin treated rats A B Intact renal tubules and
  • Figure 6 Putative gene based markers of nephrotoxicity Graph represents level of change relevant to control animals The level of expression is shown as the log2 of
  • liver Lead citrate and uranyl acetate X 7500 The cytoplasm also contained vesiculated rough endoplasmic reticulum VER and atrophied mitochondria Ma with ill differentiated cisternae Click on the image to enlarge
  • Table 3
  • Figure 2 Comparison of average log2 ratios between independent in vivo experiments Average log2 ratios for the 16 genes significantly altered in rat kidney by 5 mg
  • focal hepatic necrosis PPRCI Periportal round cell infiltration MBH Massive breakdown hepatocytes V vacuole RCI round cell infiltration Magnification A F X400 B E X250 CX160 Click on the image to enlarge Control hepatocytes were normal polygonal with oval shaped nuclei cytoplasm crowded with organelles particularly rough endoplasmic reticulum smooth
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  • Table 1 Characteristics of the Patients
  • have been studied For example the image below represents the crystal structure of a double stranded DNA decamer containing a cisplatin Pt NH3 2 interstrand cross link adduct13 References 1 S Neidle Prog Med Chem 1979 16 151 2 J B Chaires J E Herrera and M Waring Biochemistry 1990 29 2538
  • cisplatin or with one of the newer combination regimens such as gemcitabine cisplatin vinorelbine cisplatin pa***axel cisplatin pa***axel carboplatin or docetaxel cisplatin Tables 6 and 7 ROLE OF PHOTODYNAMIC THERAPY
  • Figure 1 The creatinine biosynthesis pathway is necessary for the formation of creatinine from l arginine ADP adenosine diphosphate ATP adenosine triphosphate Creatinine
  • cDDP and ADM as shown in Tab 1 The cell growth inhibitory effects of the combined treatment were synergistic and more significant compared with p73α or chemotherapeutic drug alone Figure 2 Alteration of cisplatin and adriamycin chemosensitivity caused by the transfer of p73α or p53 gene in A549 cell line
  • CDDP DNA Crosslinks Cisplatin DNA Intrastrand Crosslink Cisplatin DNA HMG Protein Komplex Synthese von Cisplatin und Carboplatin
  • Electron Ionization Mass Spectrometry of Platinum Complex Cisplatin
  • Random Tripawd Pics
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  • Figure 3 Hierarchical clustering as described by Eisen et al 1998 was applied across the various treatment groups doses and time points using a combined
  • used to locate this record in the CAS REGISTRYSM database the world s largest substance database with over 33 million organic and inorganic substances and more than 59 million sequences Using SciFinder you can easily locate relevant published research for the substance Clicking on the Microscope icon provides details of the research articles of interest
  • Table 1 Characteristics of the Patients
  • Table 2 Treatment Received and Reasons for Discontinuation
  • Cisplatin DNA Intrastrand Crosslink Cisplatin DNA HMG Protein Komplex Synthese von Cisplatin und Carboplatin Pharmakokinetik der alkylierende und platinierende Zytostatika
  • Figure 4 Clustering of gentamicin treated individual animals at 80 and 240 mg kg after 7 days of exposure These two biological exposures were conducted independently
  • Table 4 Mean FACT O Quality of Life Scores in the Two Groups at Each Assessment Point
  • Figure 1 Comparison of gene expression results for the intersection of cisplatin altered genes on the NIEHS cDNA and Affymetrix RGU34A platforms The direction of the
  • measured twice weekly at 1 4 8 12 16 and 20 days post treatment Body weight gains during the course of the treatment of both control and experimental groups were determined P < 0 05 Click on the image to enlarge
  • drugs are placed in an accelerated development and review process this will not be discussed here but is described more fully on the FDA website on the new drug development process Courtesy FDA Phase 1 clinical studies represent the first time that an IND is tested on humans generally healthy volunteers but sometimes patients the latter was the case with phase
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  • Cisplatin Carboplatin
  • Table 1
  • Figure 5 Evidence for puromycin induced tubular toxicity based on gene expression profiling A number of enzymatic and transporter functions that map to the proximal
  • toiminnallista vaikutusta mitä aiemmin on arveltukaan Eri annosten cisplatiinia havaitaan indusoivan kahta erilaista soluvastetta http tbn2 google com images q=tbn 94j 3BW5HcYAKM http dic academic ru pictures enwiki 67 Cisplatin 2D png http www rbej com content figures 1477 7827 1 66 2 jpg Matalista annoksista tulee esiin senescence solun vanhentumismuutoksia
  • of doxorubicin and 5 FU in rat liver Doxorubicin A B and 5 FU C D treatments revealed similar cytological alterations as in cisplatin treatement Lead citrate and uranyl acetate X 7500 Click on the image to enlarge

Videos
related videos for cisplatin

  • Mesothelioma - Dr. Raja Flores - Mount Sinai Hospital Dr. Raja M. Flores, Chief of the Division of Thoracic Surgery at The Mount Sinai Medical Center, is a recognized leader in the field of Thoracic Surgery for his pioneering efforts in the treatment of mesothelioma. He has established VATS lobectomy, a minimally invasive approach using three small incisions, as the gold standard in the surgical treatment of lung cancer. He published two sentinel studies validating its oncological effectiveness by demonstrating equivalent survival and recurrence rates with fewer complications and shorter hospital stays when compared to standard thoracotomy. Currently, Dr. Flores is one of the most experienced VATS lobectomy surgeons in the world. He was a lead investigator in a multicenter trial of neoadjuvant alimta/cisplatin, extrapleural pneumonectomy, and high-dose radiation, which is designed to improve outcomes. He also presented this data at the 90th Annual Meeting of the American Association for Thoracic Surgery. Dr. Flores' additional research interests are based on numerous past projects relating to the multimodality management of malignant pleural mesothelioma, as well as innovative surgical techniques in minimally invasive thoracic surgery for lung cancer. He has led a number of major studies, including clinical trials of neoadjuvant gemcitabine and cisplatin followed by extrapleural pneumonectomy and high dose radiation. Visit Dr. Raja Flores' profile: Mount Sinai Lung:
  • Norva's MALIGNANT TERATOMA DIARY PT2.wmv I was diagnosed with an immature teratoma, also known as Malignant Ovarian Germ Cell Tumor (MOGCT) in December 2010. It is a rare type of ovarian cancer which has been surgically removed. I have to take a chemotherapy regimen called bleomycin, etoposide and cisplatin (BEP) to kill remaining cancer cells. This is a video blog of my experiences.
  • Cisplatin and nephrotoxicity Video of Cisplatin and nephrotoxicity
  • Will we be hearing less about hearing loss Mark Dungan summarizes the current research regarding hearing loss from cisplatin and carboplatin as it relates to neuroblastoma.
  • 10 - Ricardo Hitt - Squamous Cell Head & Neck Cancer 1 Squamous Cell H&N Cancer-- Hypopharynx 2 Treatment of HNC: Multidisciplinary 3 Standard treatment options for HNC 4 Locoregional control and distant metastases 5 Hypopharyngeal cancer 6 Hypopharyngeal cancer: objectives 7 EORTC 24891 Ph III: PF + RT vs surgery + RT 8 EORTC 24891: Patient characterisics 9 EORTC 24891: Overal survival and DFS 10 Survival Pharyngeal SCC after definitive RT 11 Standard treatment for LA SCCHN 12 ASCO 1982: The Platinum Revolution 13 Rationale for induction CT 14 Al-Sarraf: Induction 5-FU and Cisplatin 15 MACH-NC meta ***ysis: CT and 5-Year Survival 16 How can we improve the results? 17 EORTC 24971/TAX 323 Ph III: Ind. CT + RT 18 TAX 324 Ph III: Ind. CT - CRT - Surgery 19 HNSCC: Taxotere in Locally-Advanced Disease 20 Phase III: PF ± Docetaxel vs CRT 21 CR to induction CT/CRT -- same benefit in survival? 22 Standard treatment 23 Conclusions
  • Mercapto PurineII cisPlatin-CHEMO Schroeder Diamond 25AUG10 Schroeder DIAMonds to the rescue huh? This makes the molecules easier to distinguish the different groups using the color and the artistic shapes for each situation huh???
  • The Mechanism of Cisplatin (New -HD) Cisplatin is in a class of drugs known as platinum-containing compounds used to treat various types of cancers including metastatic testicular and ovarian tumors. The molecule was first discovered in 1845, but did not receive FDA approval until 1978. Today it is known as the "penicillin of cancer drugs," because it is so effective for many different cancers. There are three key players involved in Cisplatin's mechanism: (1) Cisplatin, (2) DNA (3) and an HMG Protein. Most Cisplatin enters the body through active transport, but some molecules are passively defused through the cell membrane. Once in the nucleus, Cisplatin can form an adduct with two consecutive guanine bases within a strand of DNA. The molecule loses its chlorine atoms in exchange for the nitrogen atoms of the target guanines. Cisplatin can bond more tightly with nitrogen because nitrogen balances the platinum charge more effectively than chlorine. It is this adduct-induced DNA bend that allows binding of proteins which contain the high mobility group, HMG domain. Once the protein is bound to the DNA, it inserts a wedge-like phenyl group of phenylalanine 37 into the widened minor groove created by the bend. The tightly bound HMG protein causes destacking of the nucleotide bases, resulting in the DNA helix becoming kinked. In this way, Cisplatin can be thought of as a monkey wrench in the DNA repair system. With the HMG protein bound to the DNA, the modified strand is not repaired properly and so the cell ...
  • 02 - Autonon - Cisplatin Autonon - Song from room 1 All tracks, except 05 and 06, written by Autonon. Track 06 written by Najmal. All tracks, except 05, are produced by Kaometry records. Track 05 written and produced by Stazma All tracks mastered by Stazma Artwork by Scabage. KMTDR04. Kaometry records. 2011. Some rights reserved. Made in Germany. SUPPORT with buying it here: Autonon FB: soundcloud: kaometry FB: Twitter: soundcloud: more infos:
  • SGO 2012 - Dr. John Geisler (A cost effective ***ysis of certain Cervical Cancer Treatment options) WORD interviews Dr. John Geisler about his Abstract entitled, "Treatment of advanced or recurrent cervical cancer with cisplatin or cisplatin containing regimens: A cost effective ***ysis". This video is part of a series of video interviews from 's coverage of the Society of Gynecologic Oncology's 43 Annual Meeting on Women's Cancer® Watch the other videos from this event here:
  • Live apoptosis of stem cells with cisplatin wild type embryonic stem cells treated with cisplatin and labelled with Annexin-488 to visulaise apoptosis Jordi Carreras Puigvert
  • GRACEcast-112_Lung-Cancer_ASCO 2012 LC Highlights: Dr. Socinski on Key Trials in Small Cell LC Dr. Mark Socinski reviews key results in small cell lung cancer (SCLC) from ASCO 2012, including the SWOG 0802 trial of topotecan +/- VEGF inhibitor aflibercept and a Japanese randomized trial of cisplatin/amrubicin vs. cisplatin/irinotecan.
  • SIU Tech Expo 2011: D-methionine (D-met) as a Protective Agent Presented by Dr. Kathleen Campbell (School of Medicine, Springfield): D-met protects against radiation-induced oral mucositis, cisplatin-induced ototoxicity and other cisplatin side effects, aminoglycoside-induced hearing loss, and noise-induced hearing loss. We have completed successful small scale Phase II clinical trials for radiation-induced oral mucositis and cisplatin-induced hearing loss which have shown significant protection with oral D-met administration. D-met also provides partial protection from aminoglycoside-induced hearing loss with no antimicrobial interference in animal studies. D-met protects against noise-induced hearing loss if given before, during or even when first started up to 7 hours after noise-cessation. The US Department of Defense has funded our Phase 2 clinical trials to test oral D-met to prevent permanent noise-induced hearing loss in soldiers during weapons training. We are currently filing our Internal Review Board (IRB) and Food and Drug Administration (FDA) documents. Our research program is currently funded by the National Institutes of Health and the US Department of Defense.
  • ASCO: Neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients Dr. Jacek Gronwald, International Hereditary Cancer Centre, Poland Study to evaluate the frequency of complete pathologic response after neo-adjuvant treatment with cisplatin chemotherapy in women with breast cancer and a BRCA1 mutation.
  • Luiz Paz Ares, Spain PARAMOUNT Phase III trial results of maintenance pemetrexed plus best supportive care BSC versus placebo plus BSC immediately following induct treatm with pemetrexed + cisplatin for adv NSCLC
  • Indication Of Cisplatin Indications of Cisplatin are Solid malignancies Ovarian Cancer Bladder Cancer Testicular Cancer Contraindications are: it should not be given to pregnant ladies, nursing mothers and impaired kidney function test. Side effects: it is highly nephrotoxic, neurotoxic, ototoxic, causes electrolyte imbalances. Mode of infusion: Intravenous
  • cisplatin
  • Irinotecan - Cisplatin day 3 My video blog of Day three of an irinotecan/cisplatin cycle. Lots of entertaining hiccups!
  • Cisplatin Edited Version That Most People Will Never Find Cisplatin is in a class of drugs known as platinum-containing compounds used to treat various types of cancers including metastatic testicular and ovarian tumors. The molecule was first discovered in 1845, but did not receive FDA approval until 1978. Today it is known as the "penicillin of cancer drugs," because it is so effective for many different cancers. There are three key players involved in Cisplatin's mechanism: (1) Cisplatin, (2) DNA (3) and an HMG Protein. Most Cisplatin enters the body through active transport, but some molecules are passively defused through the cell membrane. Once in the nucleus, Cisplatin can form an adduct with two consecutive guanine bases within a strand of DNA. The molecule loses its chlorine atoms in exchange for the nitrogen atoms of the target guanines. Cisplatin can bond more tightly with nitrogen because nitrogen balances the platinum charge more effectively than chlorine. It is this adduct-induced DNA bend that allows binding of proteins which contain the high mobility group, HMG domain. Once the protein is bound to the DNA, it inserts a wedge-like phenyl group of phenylalanine 37 into the widened minor groove created by the bend. The tightly bound HMG protein causes destacking of the nucleotide bases, resulting in the DNA helix becoming kinked. In this way, Cisplatin can be thought of as a monkey wrench in the DNA repair system. With the HMG protein bound to the DNA, the modified strand is not repaired properly and so the cell ...
  • Cisplatin Project
  • Norva's MALIGNANT TERATOMA DIARY PT1.wmv I was diagnosed with an immature teratoma, also known as Malignant Ovarian Germ Cell Tumor (MOGCT) in December 2010. It is a rare type of ovarian cancer which has been surgically removed. I have to take a chemotherapy regimen called bleomycin, etoposide and cisplatin (BEP) to kill remaining cancer cells. This is a video blog of my experiences.
  • CisPlatin: Mechanism of Action (Old - SD) Cisplatin is in a class of drugs known as platinum-containing compounds used to treat various types of cancers including metastatic testicular and ovarian tumors. The molecule was first discovered in 1845, but did not receive FDA approval until 1978. Today it is known as the "penicillin of cancer drugs," because it is so effective for many different cancers. There are three key players involved in Cisplatin's mechanism: (1) Cisplatin, (2) DNA (3) and an HMG Protein. Most Cisplatin enters the body through active transport, but some molecules are passively defused through the cell membrane. Once in the nucleus, Cisplatin can form an adduct with two consecutive guanine bases within a strand of DNA. The molecule loses its chlorine atoms in exchange for the nitrogen atoms of the target guanines. Cisplatin can bond more tightly with nitrogen because nitrogen balances the platinum charge more effectively than chlorine. It is this adduct-induced DNA bend that allows binding of proteins which contain the high mobility group, HMG domain. Once the protein is bound to the DNA, it inserts a wedge-like phenyl group of phenylalanine 37 into the widened minor groove created by the bend. The tightly bound HMG protein causes destacking of the nucleotide bases, resulting in the DNA helix becoming kinked. In this way, Cisplatin can be thought of as a monkey wrench in the DNA repair system. With the HMG protein bound to the DNA, the modified strand is not repaired properly and so the cell ...
  • Autonon - Cisplatin Song from Room 1 Label: Kaometry Records Released 15 September 2011 All tracks written by Autonon Mastered by Stazma Artwork by
  • Stage III-IV Head and Neck Squamous Cell Carcinomas (HNC) From ASCO 2011 -- A discussion with Rita Axelrod, MD and Associate Professor in Medical Oncology at Thomas Jefferson University, Philadelphia, about a Randomized Phase III Trial (RTOG 0522) of Concurrent Accelerated Radiation Plus Cisplatin With or Without Cetuximab.
  • Dr. Belani Discusses NSCLC Adjuvant Therapy Chandra P. Belani, MD, Deputy Director, Penn State Hershey Cancer Institute, Miriam Beckner Distinguished Professor of Medicine, Penn State Hershey Medical Center & College of Medicine, discusses recent changes to adjuvant therapy for non-small cell lung cancer (NSCLC). Adjuvant therapy is the current standard of care for patients with resectable NSCLC. Various trials have suggested that the absolute improvement in overall survival from adjuvant treatment is 4.1-15%. Most practitioners assume an approximate 7-8% overall improvement. Recent trials have suggested that new combinations such as cisplatin and pemetrexed have an equivalent effect, and may be more feasible, than the current standard of cisplatin plus vinorelbine or etoposide, which has recently been the focus of multiple studies. While a comparison of these standards is not currently needed it has resulted in a paradigm shift in adjuvant care for early-stage resectable NSCLC, with the exception of patients with stage IA-IB that measures less than 4 cm.
  • ASCO 2009: Lung cancer patients lacking MSH2 DNA repair protein fare better with chemo Pierre Fouret, MD, PhD, Institut Gustave Roussy, Université Pierre et Marie Curie, Paris, France: Speaking at ASCO 2009: Lung Cancer Patients Lacking MSH2 DNA Repair Protein Fare Better with Chemotherapy: An ***ysis from the International Adjuvant Lung Trial (IALT) reports that tumor levels of the MSH2 protein predict long-term response to cisplatin-based chemotherapy among patients with surgically removed non-small cell lung cancer (NSCLC). MSH2 is a protein that cancer cells use to repair DNA damaged by cisplatin. Researchers found that patients with no or low levels of the MSH2 protein respond better to treatment than patients with high levels.
  • Dr. Wakelee Discusses Adjuvant Therapy in Elderly NSCLC Patients Heather Wakelee, MD, assistant professor, Department of Medicine, Division of Oncology, Stanford University, Stanford Clinical Cancer Center, explains that trials have been completed looking at adjuvant cisplatin given in 4 cycles in multiple age groups that showed an improvement in survival of 5-10%. Some trials focused on the subset of elderly patients defined as being over 65 years old. These trials found that elderly patients did not tolerate chemotherapy as well but still experience similar survival rates to the broad studies looking at multiple age groups. When examining patients in their 80's it became clear how important accurate patient selection becomes. It was difficult, but possible, to find patients in their 80's that are fit to receive chemotherapy.
  • Chemotherapy Cancer Treatments & Side Effects : Common Side Effects of Cisplatin Chemotherapy The most common side effects associated with Cisplatin chemotherapy cancer treatments are nausea, vomiting, nerve damage in the hands and feet, and hearing loss. Reduce the dosage or Cisplatin chemotherapy, or combine the treatment with other drugs, to reduce the side effects with insight from a doctor in this free video on chemotherapy and cancer treatments. Expert: Dr. David Cathcart Bio: Dr. David Cathcart has been an occupational medicine physician at Heartland Regional Medical Center in St. Joseph, Mo. for more than 20 years. Filmmaker: Johnny Cathcart
  • Gemcitabine added to standard therapy improves survival in cervical cancer NEW YORK (Reuters Health) -- Patients with advanced cervical carcinoma have better progression-free survival when gemcitabine is added to concurrent cisplatin chemoradiotherapy and included in adjuvant therapy, an international team reports in the Journal of Clinical Oncology online March 28. For more information, please visit:
  • Cisplatin, compound noted to destroy Cancer. Owen Jensen discusses how Cisplatin has the ability to bind to and destroy cancerous cells, but it also has the hazardous side effect of serious kidney damage, given the role those organs play in filtering blood.
  • Cisplatin Part 1
  • Cisplatin Part 3
  • finding cisplatin a video by johnathan w/ annie & henry about cisplatin (substance used in chemotherapy treatment) made for mandell's class! camera: annie girl: henry random characters + cisplatin: johnathan
  • [3D] The Mechanism of Cisplatin Note on 3D video: 3D videos on youtube are best viewed with a 3D viewing system such as a 3D TV or a stereoscopic 3D capable computer. There is an option for colored glasses, but youtube does the conversion so unless your glasses match youtube's specifications, they won't work as well. If you don't have a viewing system you can try the no glasses option: you can view the video in 3D by crossing your eyes to merge the left and right view, similar to how stereograms work. However this can be difficult to pull off and could give you a headache. This video is a stereoscopic rework of the original video at youtu.be Some things were modified during the rework. The original description is below: Cisplatin is in a class of drugs known as platinum-containing compounds used to treat various types of cancers including metastatic testicular and ovarian tumors. The molecule was first discovered in 1845, but did not receive FDA approval until 1978. Today it is known as the "penicillin of cancer drugs," because it is so effective for many different cancers. There are three key players involved in Cisplatin's mechanism: (1) Cisplatin, (2) DNA (3) and an HMG Protein. Most Cisplatin enters the body through active transport, but some molecules are passively defused through the cell membrane. Once in the nucleus, Cisplatin can form an adduct with two consecutive guanine bases within a strand of DNA. The molecule loses its chlorine atoms in exchange for the nitrogen atoms of the target ...
  • cisplatin
  • Cisplatin 암과 Cisplatin의 작용 Mechanism
  • 2012 SIU Tech Expo - Kathleen CM Campbell - D-methionine (D-met) as a protective agent D-methionine (D-met) as a Protective Agent: From Bench to Bedside Dr. Kathleen CM Campbell Speaking at the Southern Illinois University Technology and Innovation Expo tie.siu.edu D-met protects against radiation-induced oral mucositis, cisplatin-induced ototoxicity and other cisplatin side effects, aminoglycoside-induced hearing loss, and noise-induced hearing loss. We have completed successful small scale Phase 2 clinical trials for radiation-induced oral mucositis and cisplatin-induced hearing loss which have shown significant protection with oral D-met administration. D-met also provides partial protection from aminoglycoside-induced hearing loss with no antimicrobial interference in animal studies. D-met protects against noise-induced hearing loss if given before, during or even when first started up to 7 hours after noise-cessation. It also protects if only given prior to the noise, even if stopped one day prior to the noise exposure. The US Department of Defense (DoD) has funded our clinical trials to test oral D-met to prevent permanent noise-induced hearing loss in soldiers during weapons training. In addition, the DoD has funded work in our lab to determine if we can extend the effective rescue period for noise induced hearing loss and to determine optimal dosing for steady state and impulse noise exposures. We have received Food and Drug Administration (FDA) approval to proceed with our clinical trials. In addition, the Gynecologic Research Group (GoG) has ...
  • Cisplatin Part 2
  • Dr. Kapil Bhalla on Using HDAC Inhibitors to Sensitize TNBC to PARP Inhibitors and Cisplatin Kapil N. Bhalla, MD, chief of personalized cancer medicine at the University of Kansas Cancer Center in Kansas City, describes the findings from an in vitro study that examined treatment with histone deacetylase (HDAC) inhibitors in triple-negative breast cancer (TNBC) cells. To view more coverage from SABCS, visit
  • Chemistry in the Clouds - Periodic Table of Videos Making Cisplatinum on top of Mt Snowdon. Make a donation at John Moses group of chemists climb Mount Snowdon and synthesis the anti-cancer drug Cisplatinum (or Cisplatin) in a small tent at the summit.
  • Dr. Wakelee Discusses Adjuvant Therapy Predictive Markers Heather Wakelee, MD, assistant professor, Department of Medicine, Division of Oncology, Stanford University, Stanford Clinical Cancer Center, discusses markers currently under investigation that could be used to predict adjuvant chemotherapy benefit in lung cancer patients. DNA repair enzymes receive the most attention as potential benefit predictors of postoperative therapy. The theory in place is that if these markers are high the tumor will be more likely to build up a resistance to chemotherapy, and contrive less of a benefit. The most common marker currently being investigated is the ERCC1 DNA repair protein that is encoded by the ERCC1 gene. This marker is still under investigation, but could lead to a clearer understanding of which patients would respond the most to adjuvant cisplatin. A retrospective examination of a prognostic trial looking at untreated resected non-small cell lung cancer patients showed that ERCC1-positive patients had an increased rate of survival compared to those that are ERCC1-negative. This information suggests that ERCC1-negative patients will benefit the most from cisplatin chemotherapy.
  • D1 lynne smartbombing cancer in Israel video diary 9 jan 2012 www.kindercancerchoices.me /lynne-hazelden Day one of Chemo liposomal cisplatin . WOW.. i am ok.. find out why this has no toxicity, does not effect bone marrow, organs and does not suppress the immune system. Lynne started treatment thanks to all of you donating. Sharing her journey. Please keep donating so she can complete it! many thanks
  • Cisplatin Chemotherapy Mesothelioma Treatment | Cisplatin is a chemotherapy drug used to treat mesothelioma cancer. If you have been diagnosed with mesothelioma, call Sokolove Law at 877-446-9690 for a free legal consultation. | awe.sm

Blogs & Forum
blogs and forums about cisplatin

  • “Posts Tagged cisplatin chemotherapy' 7 Side Effects of Chemotherapy chemotherapy or heavy treatments of Cisplatin chemotherapy side effects should be”
    cisplatin chemotherapy,

  • “Blog: Simply Savings. • The stay-at-home calculator. • More calculators. • Chat in our Money Mavens forum. Style. • Blog: Style Desk Blog > Has tag 'gemcitabine and cisplatin' Feb. 18. Just As Likely. My blood counts were once again too low for treatment today”
    — Chatelaine " gemcitabine and cisplatin,

  • “Galleon : .au Forum : 2. Treatment Options : Cisplatin or Alimta Just some interesting research that has come in. Comparing Cisplatin and Alimta and specific tumour makeup”
    — Galleon : .au Forum : 2. Treatment Options, .au

  • “cisplatin based chemotherapy,pharmed.blog.hr”
    cisplatin based chemotherapy - pharmed - Blog.hr, pharmed.blog.hr

  • “cisplatin Alternative Health Blog; October, 2007 Archive; Alternative Health Blog cisplatin Alternative Health Blog; October, 2007 Archive; Alternative Health Blog. Web site copyright (c) 2007”
    cisplatin Alternative Health Blog; October, 2007 Archive, blog.health-

  • “Piroxicam, a nonsteroidal anti-inflammatory drug (NSAID), has shown anti-tumoral activity which is amplified when combined with Cisplatin. mesothelioma cell lines and treated cells with piroxicam and cisplatin alone then combined the two treatments”
    — Mesothelioma Blog " Blog Archive " Piroxicam and Cisplatin, blog.mesothelioma-

  • “The Cancer in Pregnancy Forum. Archived Questions and Answers. This Forum has been the centre of an exceptional exchange of Cisplatin is a potent and very toxic anticancer medication. In general, women are not recommended to breastfeed while undergoing”
    — The Hospital for Sick Children - Motherisk - HIV Treatment in,

  • “Forums and message boards for Platinol, Cisplatin (generic) Platinol, Cisplatin Forum. Forums and message boards for Platinol, Cisplatin (generic)”
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