capsid

Inactivating viruses with femtosecond laser pulses Del Mar Photonics Trestles femtosecond Ti:Sapphire laser is used by researchers from Arizona State University to kill viruses and bacteria. The research is described in several publications including SPIE newsroom article: KT Tsen, Shaw-Wei Tsen, Chih-Long Chang, Chien-Fu Hung, T.-C. Wu, B. Ramakrishna, and Juliann G. Kiang A new technique for targeting viral capsids may be applicable to a wide variety of pathogens. 21 December 2007, SPIE Newsroom. DOI: 10.1117/2.1200711.0928 Most antiviral and antibacterial treatments are only partially successful in eliminating target pathogens and may raise problems associated with drug resistance, adverse events, and unwanted side effects. Although UV irradiation represents an alternative, it lacks selectivity, eliminating unwanted microorganisms but also damaging other structures while raising concerns over harmful mutations. New methods to circumvent these limitations are particularly desirable. One experimental technique involves microwave absorption with a view to destroying microorganisms by exciting their vibrational states.1,2 But water, the basic environmental medium for most undesirable microorganisms, readily absorbs microwave energy in the range of 10-300GHz, which also happen to be the typical vibrational frequencies of viral capsids (shells).3,4 In general, it is extremely difficult to affect the vibrational energy of microorganisms. Overcoming this drawback will require, in place of microwave excitation, visible ...

Virus capsid 3IZG Virus capsid 3IZG Created by ProteinInsight()

Paramecium Bursaria Chlorella Virus Capsid Structure Assembly of PCBV-1 (Paramecium Bursaria Chlorella Virus 1) capsid.

Tetsuo Tongue-in-cheek homage to Tetsuo the Iron Man, made in our front yard. From /capsid, , and .

hiv virus credit to the owner explaination: HIV enters macrophages and CD4+ T cells by the adsorption of glycoproteins on its surface to receptors on the target cell followed by fusion of the viral envelope with the cell membrane and the release of the HIV capsid into the cell. Entry to the cell begins through interaction of the trimeric envelope complex (gp160 spike) and both CD4 and a chemokine receptor on the cell surface. gp120 is bound with the CD4 protein, the envelope complex undergoes a structural change, exposing the chemokine binding domains of gp120 and allowing them to interact with the target chemokine receptor. After HIV has bound to the target cell, the HIV RNA and various enzymes, including reverse transcriptase, integrase, ribonuclease, and protease, are injected into the cell.During the microtubule-based transport to the nucleus, the viral single-strand RNA genome is transcribed into double-strand DNA, which is then integrated into a host chromosome. Shortly after the viral capsid enters the cell, an enzyme called reverse transcriptase liberates the single-stranded (+)RNA genome from the attached viral proteins and copies it into a complementary DNA (cDNA) molecule.Together, the cDNA and its complement form a double-stranded viral DNA that is then transported into the cell nucleus. The integration of the viral DNA into the host cell's genome is carried out by another viral enzyme called integrase.During viral replication, the integrated DNA provirus is transcribed ...

poliovirus: capsid, encapsidation Here is an animation for the following processes in the poliovirus life cycle.

Electrostatic properties of a viral capsid during swelling This video shows the changes in electrostatic properties in the interior of a capsid induced during swelling. The calculations were performed with APBS by Robert Konecny as part of a collaboration between the Baker, Brooks, and McCammon groups.

tailgate metal by CAPSID our first recorded song. lead guitarist is eric ard. rythym guitarist (right) cody wheeler. rythym guitarist(left) austin ard. LEAD GUITARIST HAS NO EFFECTS AND LISTEN HOW HE PLAYS.

Virus capsid 3N09 Virus capsid 3N09 Created by ProteinInsight()

Construction of a Cylindrical HIV Capsid This movie shows a cylinder constructed of HIV capsid "CA" proteins, which is being simulated to help us understand the detailed interactions between the CA proteins. Normally, HIV capsids are cone-shaped structures built from hexameric and pentameric CA protein oligomers, but cylindrical structures like the one shown here, can spontaneously assemble in lab situations. This cylindrical HIV capsid was constructed to match experimental data, and is a first step towards building a realistic atomic model of a "real-life" conical HIV capsid. See this site for more information: www.ks.uiuc.edu Related papers: Yeager, M. (2011) Design of in Vitro Symmetric Complexes and ***ysis by Hybrid Methods Reveal Mechanisms of HIV Capsid Assembly. Journal of Molecular Biology, 410, 534-552 ***illos, O., Ganser-***illos, B., and Yeager, M. (2011) Atomic-level modelling of the HIV capsid. Nature, 469, 424-427.

ADENOVIRUSES PRESENTED IN HD An animated overview of Adenoviruses. Adenoviruses are non-enveloped icosahedral capsid particles. The capsid is built from 252 individual capsomer units. 12 fibrous penton fibers extend from apical capsomers and mediate host attachment, which are easily detached during preparation for electron microscopy. Adenoviruses cause mild diseases that include conjunctivitis and respiratory illness. During preparation for electron microscopy, penton fibers may separate from the apical capsomers. Adenoviruses do not have envelopes, and as a consequence, after they assemble in the cells of the infected individual, the host cell must be sacrificed (lysed) in order for the nucleocapsids to be disseminated and continue their replicative cycle.

run from the maggot by CAPSID this song was wrote by band member austin ard. original song.

Virus capsid 1a6d rendered with ProteinInsight

Fastest assembly pathway of a T=1 capsid shell This movie shows a low activation energy pathway from an open configuration towards a perfectly closed icosahedral shell, using rigid building blocks interacting via the Morse potential (blue) and 'polarised' repulsive Lennard-Jones terms (red and yellow). Journal reference: Fejer, SN; James, TR; Hernandez-Rojas, J and Wales, D, PCCP, 11(12), 2098-2104 (2009).

Capsid assembly and DNA encapsidation Peng L, Ryazantsev S, Sun R, Zhou ZH. Three-Dimensional Visualization of Gammaherpesvirus Life Cycle in Host Cells by Electron Tomography. Structure. Jan 13 2010;18(1):47-58.

EXPLORING THE INSIDE OF A VIRUS WITH A HELICAL CAPSID IN HD The tobacco mosaic virus is a plant virus that has a helical capsid. It is a good example of a virus with a helical capsid. The capsid is like a slinky composed of many individual protein subunits. The RNA phosphate (shown in color) backbone stabilizes the interaction between the RNA and coat protein (shown in transparent grey). A helical aggregate of protein subunits frames a spiraling RNA molecule that contains the genetic information necessary for replication in the host. The coat protein assembles into a rod-like structure. The "capsid" is the protein shell surrounding the nucleic acid genome, and the nucleocapsid is the nucleic acid and protein which gets packaged into the virion. (ie the nucleocapsid of TMV forms long rods that get incorporated into the TMV virion.) The virion is the complete infectious viral particle. It contains the nucleocapsid (green), a few proteins (not portrayed in this animation) and sometimes a viral envelope.

Virus capsid 2XPJ Virus capsid 2XPJ Created by ProteinInsight()

PhiX 174 Virus Capsid Assembly Schematic animation of PhiX 174 virus assembly (capsid protein: blue, major spike protein: orange).

Virus capsid 3N7X Virus capsid 3N7X Created by ProteinInsight()

Capsid: Thursday -04- Tinged Mort: Guitar & Vocals Michael Scott: Bass Zac Nelson: Drums Invite Only Performance Crossroads School Road Eldorado, IL Fall 1998

Herpes Icosahedral Capsid in HD Herpes nucleocapsid animation

Herpes simplex virus type I B-capsids More virus images and movies on virusworld: virology.wisc.edu Rendering of electron density map 5259. EM data from Primary citation: RH Rochat, X Liu, K Murata, K Nagayama, FJ Rixon, W Chiu Seeing the portal in herpes simplex virus type 1 B capsids. J. Virol., Vol. 85, Issue 4, Page 1871-4, Year 2011 More movies: More info about virus at : More virus images and movies on virusworld: virology.wisc.edu Image renderings by Jean-Yves Sgro. © 2011

CAPSID in concert Battle of the Bands - Langford, BC - June 6, 2008

Capsid Animation of Human Papilloma Virus 16, HPV 16 in HD Major late protein L1 forms the pentameric viral shell of human papilloma virus according to journal authors at Harvard University. Expression of the capsid protein in E. coli makes them a promising candidate for HPV vaccination production, and this structure was suggested to be a good starting point for the future design of vaccines against the virus. Citation of PDB 1DZL Animated by Christopher Leggett

Kaebin Yield - The Reconfigured Capsid www.entity.be

Grabbing the Cat by the Tail: Discrete Steps by a DNA Packaging Motor Air date: Wednesday, September 07, 2011, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local Category: Wednesday Afternoon Lectures Description: As part of their infection cycle, many viruses must package their newly replicated genomes inside a protein capsid to insure its proper transport and delivery to other host cells. Bacteriophage phi29 packages its 6.6 mm long double-stranded DNA into a 42 nm dia. x 54 nm high capsid using a multimeric ring motor that belongs to the ASCE (Additional Strand, Conserved E) superfamily of ATPases. A number of fundamental questions remain as to the coordination of the various subunits in these multimeric rings. The portal motor in phi29 is ideal to investigate these questions. Using optical tweezers, we find that this motor can work against loads of up to ~57 picoNewtons on average, making it one of the strongest molecular motors ever reported. Interestingly, the packaging rate decreases as the prohead is filled, indicating that an internal pressure builds up due to DNA compression. The capsid pressure at the end of the packaging is ~6 MegaPascals, corresponding to an internal force of ~52 pN acting on the motor. We have identified where in the mechanochemical cycle the chemical energy of ATP is converted into mechanical work. Using ultra-high resolution optical tweezers, we have performed the first direct measurement of the step size of a translocating ring ATPase. What emerges is a surprising mechanism that involves a step ...

Viral capsids.mov This is a slideshow depicting viral capsids assembled with different types of octahedral panels. Spokes of two types are shown for a three-triplet panel capsid--icosahedral vertexial and icosahedral facial. The spokes are shown in two icosahedral projections--facial and edgial. Electron micrographic peaks are related to the topology of the octahedral panels in edgially viewed icosahedral capsids.

Capsid: Thursday -02- Go Away Mort: Guitar & Vocals Michael Scott: Bass Zac Nelson: Drums Invite Only Performance Crossroads School Road Eldorado, IL Fall 1998

Pushing Down on a Virus Capsid To understand how viruses break open in and infect the human body, scientists need to investigate the physical/mechanical properties of the virus body (a capsid). The movie shows a pointer (bronze, rounded grid on top) pushing down on a hepatitis B virus capsid (red, green, blue, yellow sphere), with the inside of the capsid shown halfway through the movie. Visit the site below for more information: www.ks.uiuc.edu

Cylindrical HIV Capsid Assembly HIV capsids are normally asymmetric, cone-shaped assemblies formed out of hexameric and pentameric oligomers of the HIV "CA" protein. However, cylindrical capsid constructs can form from the self-assembly of CA-hexamers in artificial lab situations. These cylindrical capsids are interesting because it is believed that the curvature and interactions of the CA-hexamers is very similar to what is found in real-life capsids, which are harder to study. This movie shows a piece of cylindrical capsid that was constructed to match experimental data. Simulating the cylindrical capsid and observing the characteristics of the CA-hexamers will be the first step towards eventual construction of a realistic cone-shaped HIV capsid. See this site for more information: www.ks.uiuc.edu Related papers: Yeager, M. (2011) Design of in Vitro Symmetric Complexes and ***ysis by Hybrid Methods Reveal Mechanisms of HIV Capsid Assembly. Journal of Molecular Biology, 410, 534-552 ***illos, O., Ganser-***illos, B., and Yeager, M. (2011) Atomic-level modelling of the HIV capsid. Nature, 469, 424-427.

Capsid: Thursday -01- Intro / Yikes! Mort: Guitar & Vocals Michael Scott: Bass Zac Nelson: Drums Invite Only Performance Crossroads School Road Eldorado, IL Fall 1998

Rhinovirus capsid Based on PDB entry 1RHI: HUMAN Rhinovirus 3 Coat Protein. This journey takes us from inside the capsid to the outside.

Capsid: Thursday -05- Break / In Her Hands Mort: Guitar & Vocals Michael Scott: Bass Zac Nelson: Drums Invite Only Performance Crossroads School Road Eldorado, IL Fall 1998

Dr Nic Stonehouse Virus Capsid.wmv Dr Nic Stonehouse, senior lecturer in the Institute of Molecular and Cellular Biology at the University of Leeds, talks us through one of the teaching aids she has 'in her drawer'. What's in your drawer? is an occasional series of blogs highlighting the weird and unusual teaching aids that researchers use to inform, enthuse and inspire their students. Contributions are welcome. Please email jo@

Virology | What Are Virus Capsids? (p4) Structures & Triangulation Numbers Information about the Virus Capsid and its properties. What are Virus Capsids? Created by Mind4Study for Educational and Research purposes in the area of Virology, a branch of Microbiology in the life sciences.

paper-viral capsid AR.mpg Folded paper model of a virus capsid (poliovirus) augmented with symmetrical capsid assembly.

Virus capsid 2CSE Virus capsid 2CSE made by proteinInsight()

Capsid Assembly and phage production Growth and Development of phage T7, limit time 12 minutes. AB proteins is Major Capsid Protein which is asembled to form procapsid T7 is the final particle. There are other molecular species not plotted here.

capsid - Computerized Angioplasty Sensor Inflation Device For more information about the capsid device, visit: And capsid-

HSV encapsidation This short animated video shows the fourth stage of the Herpessimplex virus infection - the creating of the capsid and the encapsidation. During encapsidatin the virus inserts its genom inside the capsid and leaves the nucleus while migrating towards the cytoplasm.

Capsid: Thursday -03- 32° Mort: Guitar & Vocals Michael Scott: Bass Zac Nelson: Drums Invite Only Performance Crossroads School Road Eldorado, IL Fall 1998

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