autophagy

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Examples
autophagy's examples

  • This process of internal house-cleaning in the cell is called autophagy—literally self-eating—and it is now considered the second form of programmed cell death (PCD) Klionsky, who has been studying autophagy in yeast, has written a. — “University of Michigan News Service”, ns.umich.edu
  • autophagy n. The process of self-digestion by a cell through the action of enzymes originating within the same. — “autophagy: Definition from ”,
  • For the disambiguation page, see Autophagy (disambiguation). (A) Diagram of autophagy; (B) Electron micrograph of autophagic structures in the fatbody of a fruit fly larva; (C) Fluorescently labeled autophagosomes in liver cells of starved mice. — “Autophagy (cellular) - Wikipedia, the free encyclopedia”,
  • Yeast autophagy is an essential process that consists of selective degradation of cellular components, depicted here as several "pac-men" gobbling up Submit your paper to Autophagy. Autophagy utilizes an online submission and tracking system designed to provide efficient service to authors. — “Landes Bioscience Journals: Autophagy”,
  • Autophagy is eating oneself, as applied to the single cell. Autophagy' commonly is reserved for the macro situation, where a large non-foreign structure is enclosed in a double membrane - the autophagosome, before being fused with lysomes for destruction. W Beresford. MICROAUTOPHAGY. — “Autophagy PowerPoint”, wberesford.hsc.wvu.edu
  • abgent.title Autophagy. Stem Cell. Apoptosis. Protein Modification. Sumoylation. Ubiquitination. Phosphorylation. Methylation. Acetylation. Glycosylation. Neurosciences. Cell Function. Cell Cycle Regulation. Cancer. Cell Membrane. Cell Signaling. Cell Structure. Metabolism. — “Abgent - Primary Antibody Company”,
  • As the Drosophila larva gets ready to pupate, the rising level of ecdysone triggers autophagy and programmed cell death in cells no longer needed in the adult (e.g., salivary gland cells). Mice lacking certain of the genes needed for autophagy die early in embryonic development. — “Autophagy”,
  • Autophagy within the cell is relevant both to the disease process and the design of treatments for Huntington's. New work is adding to scientists' knowledge. — “More about autophagy”,
  • Is the decrease in blood lipids a consequence of every cell in the body upregulating autophagy and therefore needing more cholesterol and triglycerides in order to rebuild membrane-bound organelles, or is this a consequence of the drug acting mainly on specific tissues/organs?. — “Autophagy " Ouroboros”,
  • Autophagy has been shown to play roles in a wide variety of normal physiological processes including energy metabolism, organelle turnover, growth regulation, and aging. Impaired autophagy can lead to diseases such as cardiomyopathy and cancer. — “Human Autophagy PCR Array”,
  • Autophagy is a catabolic process in which a cell degrades some of its contents by delivering them to the lysosomal pathway. When cells are starved for important nutrients, autophagy works overtime to degrade the less crucial cellular paraphernalia,. — “Autophagy: Recycling Thats Both Helpful And Harmful”,
  • The processing and degradation of cytoplasmic components and organelles by the lysosome/vacuole is known as autophagy ("self-eating" Autophagy plays a role in development, aging, immunity and cell death and in human has been associated with cancer, neurodegeneration and certain. — “Autophagy | Boston Biochem”,
  • According to a recent ***ysis of Essential Science Indicators SM from Thomson Reuters, the journal Autophagy is having a growing impact in the field of Biology & Biochemistry. Its record in this field includes 414 papers cited a total of 2,692 times from its launch in 2005 to February 28, 2009. — “Autophagy - ”,
  • Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum Here, we have identified a novel role for androgens in the modulation of autophagy. — “Cell Death and Disease - Androgens modulate autophagy and”,
  • Autophagy also appears to be one of the cellular strategies to cope with micro-organisms (Kirkegaard et al, 2004) A hallmark of the autophagy processes is the development of endogenous autophagosomes (autophagic vacuoles), which are most conveniently visualized by electron. — “Autophagy (Cytokines & Cells Encyclopedia - COPE)”,
  • Autophagy is a ubiquitous cellular process responsible for the bulk degradation of cytoplasmic components through an autophagosomal-lysosomal pathway. Genetic screens, primarily in S. cerevisiae, have identified numerous genes that are essential for autophagy. — “Autophagy in C. elegans”,
  • Autophagy plays a key role in diverse pathologies, including infections, cancer, neurodegeneration and aging as well as in heart, liver and kidney diseases (read more) All these studies have increased the number of autophagy related genes and proteins reported. — “HADb : Human Autophagy Database”, autophagy.lu
  • Autophagy is essential in helping to maintain the balance between the increase and decrease in the number of a cell population. Autophagy is a housekeeping process whereby long-lived proteins and organelles are recycled e.g. Mitochondria (22). — “Autophagy: an overview | Abcam”,
  • Autophagy: The Other. Autophagy: The Other. Programmed Cell Death. Programmed Cell Death. Degradation of organelles and cellular There are 16 known autophagy genes (ATG's) most of which are conserved in higher. most of which are conserved in. — “Microsoft PowerPoint - autophagy_Errika”, life.umd.edu
  • of most short-lived proteins, and autophagy, a process induced by nutrient lim There exist multiple types of autophagy, which differ mainly in the. — “Part I Introduction to Autophagy”,

Videos
related videos for autophagy

  • Rahul's Autophagy Project My Presentation about a project i did at Fox Chase
  • 3C03 Wiki - Figure 5 Overall Interpretation.mp4 Overall ***ysis and interpretation of Figure 5 in article by Ravikumar et al. (2010). Series of powerpoint slides. Created by AL. Part of BIOCHEM 3C03 Wiki on Autophagy for AL
  • Baby Octopus I filmed this baby octopus while night diving in the La Jolla Cove on Jan. 13 2008. The water temp. was a brisk 52 digrees. Octopuses are characterized by their eight arms (not tentacles), usually bearing suction cups. These arms are a type of muscular hydrostat. Unlike most other cephalopods, the majority of octopuses — those in the suborder most commonly known, Incirrina — have almost entirely soft bodies with no internal skeleton. They have neither a protective outer shell like the nautilus, nor any vestige of an internal shell or bones, like cuttlefish or squids. A beak, similar in shape to a parrot's beak, is the only hard part of their body. This enables them to squeeze through very narrow slits between underwater rocks, which is very helpful when they are fleeing from morays or other predatory fish. The octopuses in the less familiar Cirrina suborder have two fins and an internal shell, generally lessening their ability to squeeze into small spaces. Octopuses have a relatively short life span, and some species live for as little as six months. Larger species, such as the North Pacific Giant Octopus, may live for up to five years under suitable circumstances. However, reproduction is a cause of death: males can only live for a few months after mating, and females die shortly after their eggs hatch. They neglect to eat during the (roughly) one month period spent taking care of their unhatched eggs, but they don't die of starvation. Endocrine secretions from the two ...
  • Intermittent Fasting for Heath and Longevity (1) Part 1 of 5 of a lecture on the benefits of intermittent fasting by Todd Becker, delivered May 18, 2011 at The Third Door in Palo Alto, California. For more information, see bit.ly
  • Zinc(II) ion mediates tamoxifen-induced autophagy and cell death in MCF-7 breast cancer cell line From the Springer article: Zinc(II) ion mediates tamoxifen-induced autophagy and cell death in MCF-7 breast cancer cell line by: Hwang, Jung Jin; Kim, Ha Na; Kim, Jean; Cho, Dong-Hyung; Kim, Mi Joung; Kim, Yong-Sook; Kim, Yunha; Park, Sung-Jin; Koh, Jae-Young; Live cell confocal microscopic images (1 minutes/frame) of a MCF-7 cell stained with FluoZin-3. Cells were treated with 17 μM tamoxifen and images were obtained from z-series collection (33 z-section images of 1 μm thickness) for 90 minutes. (AVI 483 kb) Journal: BioMetals Vol. 23 Issue 6 DOI: 10.1007/s10534-010-9346-9 Published: 2010-11-08
  • Wumpscut - Ain't That Hungry Yet Wumpscut Ain't That Hungry Yet Body Census
  • Cell Death, Autophagy and CVD - BCVS 2011 Richard Kitsis, MD, FAHA and Yoshinori Ohsumi, PhD discuss cell death, autophagy and cardiovascular disease during AHA's Basic Cardiovascular (BCVS) 2011 Scientific Sessions held at the Ritz-Carlton Hotel in New Orleans, Louisiana on July 18-21, 2011.
  • Why Humans Age While resveratrol has recently gained widespread public and scientific attention for it age prolonging qualities, Longevinex® is a unique multi-ingredient dietary supplement that is more than just resveratrol. The ingredients in Longevinex® are designed to address five major theories of aging: the free radical/antioxidant theory, the hormonal theory (estrogen/testosterone), the mitochondrial (cell energy) theory, the cell cleansing or autophagy theory, and the metabolic, calorie restriction/Sirtuin gene activation theory. There is another theory of aging, Overmineralization, also addressed by the ingredients in Longevinex®, which may supercede and better explain other theories of aging.
  • baby autophagy The baby is still working out the details of this whole "thumb sucking" paradigm. On average, pacifier is still less likely to get away.
  • Antitumor Properties of Cannabinoids - Dr. Jeffrey Hergenrather MD Antitumor Properties of Cannabinoids - Dr. Jeffrey Hergenrather MD Antiproliferative, Antiangiogenic, Antimetastatic, Apoptotic, Apoptosis, Autophagy Dr. Jeffrey Yates Hergenrather, MD: Jeffrey Hergenrather, MD: http facebook: The UKCIA News Blog: Amazon (buy it!!):
  • :Wumpscut: - Autophagy Day (Advent Resilience Remix)
  • THE SELFCANNIBAL MONSTER "THE SELFCANNIBAL MONSTER" - video and music and artworks by (b)ananartista orgasmo sbuff: http ---- A monster is any fictional dangerous or hideous creature, usually in legend or horror fiction. The word monster derives from the Latin word monstrum, meaning "omen", from the root of monere ("to warn") and also meaning "prodigy" or "miracle". The word connotes something wrong or evil; a monster is generally morally objectionable, physically or psychologically hideous, and/or a freak of nature. It can also be applied figuratively to a person with similar characteristics. Monsters are commonly used in fantasy or role-playing games, especially role-playing video games, when a large number of enemies to fight against are needed. However, the idea has been used across every genre to varying degrees. These can include aliens, all types of legendary creatures, or mutated versions of regular animals. However, sentient fictional races are usually not referred to as monsters. Other times, the term can carry a neutral connotation, such as in the Pokémon franchise, where it is used to refer to fictional creatures that may resemble, but are not, real world animals. Characters in games may refer to all animals as "monsters". Self-cannibalism is the practice of eating oneself, also called autocannibalism,[1] or autosarcophagy.[2] A similar term which is applied differently is autophagy, which specifically denotes the normal process of self-degradation by cells. While ...
  • Autophagy, a guardian against neurodegeneration - Part 2 The Fifth SENS conference (2011) David Rubinsztein - University of Cambridge, UK Intracellular protein misfolding/aggregation are features of many currently incurable late-onset neurodegenerative diseases, like Alzheimer's disease, Parkinson's disease and polyglutamine expansion diseases like Huntington's disease (HD) and various spinocerebellar ataxias. The mutations causing many of these diseases confer novel toxic functions on the target proteins. We showed that the autophagy inducer, rapamycin, reduced the levels of mutant huntingtin and attenuated its toxicity in cells, and in Drosophila and mouse HD models. We have extended the range of intracellular proteinopathy substrates that are cleared by autophagy to other related neurodegenerative disease targets and have provided proof-of-principle in cells, Drosophila and mice. In order to induce autophagy long-term, we have been striving to identify safer alternatives to the mTOR inhibitor, rapamycin. To this end, we have been trying to discover novel components of the autophagy machinery and new signalling pathways and drugs that impact on autophagy. While autophagy induction is protective in models of various neurodegenerative diseases, certain other conditions, including lysosomal storage disorders, are associated with compromised autophagy. I will review these data and then describe how impaired autophagy compromises cellular processes, including the ubiquitin-proteasome system.
  • Dr. Fusheng Tang: UALR Faculty Excellence Enthusiasm for Discovery Dr. Fusheng Tang, a cell biologist, holds a well-earned reputation having an enormous enthusiasm for discovery that keeps him at the laboratory until all hours evidenced by the bedroll he keeps in his office. His steadfast dedication extends to his preparation and imagination in the classroom. Tangs enthusiasm for discovery is reflected in 10 published papers on the process of aging in prestigious scientific journals including Nature, Journal of Cell Biology, and Autophagy. He received a two-year grant from the American Heart Association, which led to the discovery of a key step in the regeneration of the lysosomal membrane. Dr. Tang and his students are now studying how blood vessel endothelial cells transport cholesterols to and from the lysosomal membrane, a risk factor for cardiovascular diseases. He is also studying how cells get rid of damaged materials through autophagy, the process of cell degradation. Dr. Tang earned a BS degree in biology from Central China Normal University in 1984 and an MS degree in genetics in 1987 from the Institute of Genetics at the Chinese Academy of Sciences. He received a Ph.D. in biochemistry in 2002 from the University of Iowa. He teaches genetics and brings his research into the undergraduate classroom of UALR.
  • The Human Genome at 10: An Overview - Eric Lander, Ph.D. A Decade with the Human Genome Sequence: Charting a Course for Genomic Medicine NHGRI hosted a day-long scientific symposium on Friday, Feb. 11, 2011, 8:30 am - 5:00 pm at the Ruth L. Kirschstein Auditorium, Natcher Conference Center on the National Institutes of Health (NIH) campus. The goal of the symposium was to offer the NIH community an exciting glimpse into contemporary genomics research, illustrating how genomics can be used to further medical discoveries and how genomics relates to individuals, communities and societies. More: www.genome.gov
  • Marijuana Kills Brain Cancer Cells in Humans Daily News @ RevolutionNews.US ~ Guillermo Velasco and colleagues, at Complutense University, Spain, have provided evidence that suggests that cannabinoids such as the main active component of marijuana (THC) have anticancer effects on human brain cancer cells. In the study, THC was found to induce the death of various human brain cancer cell lines and primary cultured human brain cancer cells by a process known as autophagy. Consistent with the in vitro data, administration of THC to mice with human tumors decreased tumor growth and induced the tumor cells to undergo autophagy. As ***ysis of tumors from two patients with recurrent glioblastoma multiforme (a highly aggressive brain tumor) receiving intracranial THC administration showed signs of autophagy, the authors suggest that cannabinoid administration may provide a new approach to targeting human cancers. Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells Story Source The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Journal of Clinical Investigation, via EurekAlert!, a service of AAAS. Cannabis Cures Cancer - "Run From The Cure ... 58 min - 7 Mar 2008 Repost from IAMHEMP420: ------ "Educate and inform the whole mass of the people... They are the only sure reliance for the preservation of our liberty." —Thomas Jefferson Time For A New American Revolution ...
  • Friday Afternoon for Pexophagy Lovers... This is for hard core fans of organelle degradation pathways...provided by AndyT on occasion of his soon - to - be LabTalk
  • LYSOSOME, B*TCH! the latest from AP Biology duo Ryamsome and Notorious HIV. This one's called Lysosome, B*TCH!. Enjoy. (ooooh oooh) Cheah. Notorious HIV and cho' boy Rhymasome here. We got a little somethin' to say. Alright, let's go. Small in size but I advise you not to be unwise, You'll meet your own demise - your cries risin' to the skies Like the other guys who got the very same surprise Brace yo'self cuz you'll be seein' spots before your bleary eyes. Food particles, Virus molecules, Bacterium - Don't need 'em. Worn out organelles? This is my cell, don't dwell or else we'll repel, dispel, so long, farewell I'll send you all straight to hell. The name's Latin, but don't grin before I begin. "Lysis": Destruction. It's part of my construction. And "Some"? It's 'body' from which I'll destroy you within, Dissolve yo' thin skin for yo' sins, goin' in for the win. Got Chems to set you ablaze there's Lipase, and Carbohydrase Protease and Nuclease and the ways Phosphoric acid slays will amaze, bring appraise and bring about the end of your days! - - - - - - - So bring your friends and we'll show 'em. Why this cell here is what i call my home. Biologists call me a "suicide-bag" But you can just call me LYSOSOME!! When you're sittin' at home, we be out on the roam, an' you be watchin' for (sung) LY - SO - SOME From Paris to Rome, We be countin' our chrome, an' you be watchin' for (sung) LY - SO - SOME When you sittin' at home, We got bling on our dome, and you be watchin' for (sung) LY - SO ...
  • Roku Ren Kugi Punch - Six hit nail punch Pretty pissed off and suffering from autophagy, Toriko nails the black GT Robo with a pretty neat combo ending in a 6 hit nail punch. Can't wait for next episode ^^
  • Science Talk: Faulty Clean-up Process May Be Key Event in Huntington's Disease www.einstein.yu.edu - In a step towards a possible treatment for Huntington's disease, scientists at Albert Einstein College of Medicine of Yeshiva University have shown for the first time that the accumulation of a mutated protein may explain damaging cellular behavior in Huntingtons disease.
  • Insidermedicine In 60 - September 8, 2011 From Toronto - Risk of developing COPD is significantly higher than the risk of developing many common cancers, according to a report published in the Lancet. Researchers reviewed health data on the entire population of Ontario (approx. 13 million people). Results showed that the average 35 year old woman was 3x more likely to develop COPD than breast cancer, and the average 35 year old man was 3x more likely to develop COPD than prostate cancer. From Ottawa - Canadian scientists have discovered a natural process that removes cholesterol, according to a report published in Cell Metabolism. Researchers found that the ancient 'autophagy' pathway digests cholesterol and removes it from arterial walls, a process that could potentially be used to reverse atherosclerosis. And finally, from Finland - Research published in the British Medical Journal finds that alcohol has become a prevalent cause of death among patients with type 1 diabetes. Researchers studied over 17000 type 1 diabetics, finding that alcohol and drugs accounted for 39% of deaths that occurred in the first 20 years of diabetes..
  • Reuben Shaw - Salk Institute - 12-23-2010 How cells running on empty trigger fuel recycling - December 23, 2010 LA JOLLA, CA--Researchers at the Salk Institute for Biological Studies have discovered how AMPK, a metabolic master switch that springs into gear when cells run low on energy, revs up a cellular recycling program to free up essential molecular building blocks in times of need. In a paper published in the Dec. 23, 2010 edition of Science Express, a team led by Reuben Shaw, PhD., Howard Hughes Medical Institute Early Career Scientist and Hearst Endowment assistant professor in the Salk's Molecular and Cell Biology Laboratory, reports that AMPK activates a cellular recycling process known as autophagy by activating an enzyme, known as ATG1, that jumpstarts the process. The newly uncovered direct molecular connection between AMPK and ATG1 is significant because dysfunctions in both AMPK signaling and autophagy are implicated in a plethora of aging-related diseases, including type II diabetes, cancer, and neurodegenerative diseases such Parkinson's and Alzheimers. Learn more at Salk.edu
  • New Fat‐fighting Pathway Discovered New Fat‐fighting Pathway Discovered | Learn about new discoveries in the way our bodies process fat in this news segment from WLS News
  • Wumpscut. ***it 6 - Autophagy Day ....
  • The Study of Akt - Section 2 of 3.mp4 This section of "The Study of Akt" focuses on three different target groups: • Effects on Proliferation and Survival • Effects on Protein Synthesis through Regulation of mTOR • Regulation of Autophagy through mTOR Visit to download the Akt Signaling Pathway and to see antibodies directed against Akt.
  • Immunolabelling of the Golgi and autophagosomes HeLa cells were transduced with Premo™ Autophagy sensor LC3B-RFP wt (green). 24 hours after transduction, cells were treated with 50uM chloroquine. The following day, cells were stained with rabbit anti-LC3B IgG, followed by an Alexa Fluor® 647 (red) conjugated secondary goat anti-rabbit IgG.Hoechst 33342 (1ug/mL, pink) was used to label nuclei. The distribution of LC3B-RFP wt overlaps with anti-LC3B IgG distribution suggesting that there is no differential partitioning of endogenous and exogenous LC3B following transduction of cells with wild type LC3B-FP chimeras. AZ section was taken of a cell in mitosis at 1um intervals and compressed in a maximum projection
  • LIFE SCIENCES | Methods in Enzymology (2) The Autophagy Series Methods in Enzymology (MIE) is one of the most highly respected publications in the field of biochemistry. In this video, editors John Abelson and Mel Simon talk about the 3-volume autophagy series edited by Daniel Klionsky.
  • SENS5 - Autophagy, a guardian against neurodegeneration - Part 1 The Fifth SENS conference - David Rubinsztein - Intracellular protein misfolding are features of many currently incurable late-onset neurodegenerative diseases, like Alzheimer's disease, Parkinson's disease and polyglutamine expansion diseases like Huntington's disease (HD) and various spinocerebellar ataxias. The mutations causing many of these diseases confer novel toxic functions on the target proteins. We showed that the autophagy inducer, rapamycin, reduced the levels of mutant huntingtin and attenuated its toxicity in cells, and in Drosophila and mouse HD models. We have extended the range of intracellular proteinopathy substrates that are cleared by autophagy to other related neurodegenerative disease targets and have provided proof-of-principle in cells, Drosophila and mice. In order to induce autophagy long-term, we have been striving to identify safer alternatives to the mTOR inhibitor, rapamycin. To this end, we have been trying to discover novel components of the autophagy machinery and new signalling pathways and drugs that impact on autophagy. While autophagy induction is protective in models of various neurodegenerative diseases, certain other conditions, including lysosomal storage disorders, are associated with compromised autophagy. I will review these data and then describe how impaired autophagy compromises cellular processes, including the ubiquitin-proteasome system.
  • SENS5 - Parasitic metabolic coupling in cancer The Fifth SENS conference - Michael Lisanti - SENS5 - Parasitic metabolic coupling in cancer Understanding oxidative stress and autophagy in the tumor microenvironment Author: MP Lisanti Kimmel Cancer Center, Jefferson, USA; Manchester Breast Centre, UK Cancer cells do not exist as pure homogeneous populations in vivo. Instead they are embedded in "cancer cell nests" that are surrounded by stromal cells, especially cancer associated fibroblasts. Thus, it is not unreasonable to suspect that stromal fibroblasts could influence the metabolism of adjacent cancer cells, and visa versa. In accordance with this idea, we have recently proposed that the Warburg effect in cancer cells may be due to culturing cancer cells by themselves, out of their normal stromal context or tumor microenvironment. In fact, when cancer cells are co-cultured with fibroblasts, then cancer cells increase their mitochondrial mass, while fibroblasts lose their mitochondria. An in depth ***ysis of this phenomenon reveals that aggressive cancer cells are "parasites" that use oxidative stress as a "weapon" to extract nutrients from surrounding stromal cells. Oxidative stress in fibroblasts induces the autophagic destruction of mitochondria, by mitophagy. Then, stromal cells are forced to undergo aerobic glycolysis, and produce energy-rich nutrients (such as lactate and ketones) to "feed" cancer cells. This mechanism would allow cancer cells to seed anywhere, without blood vessels as a food ...
  • HIF skit for Burke Retreat 2011.MOV HIF, CM Inside the cell a crowded brew of ions and enzymes allows the gene expression rates to vary with the climes. This is a tale of oxygen, and how the cell detects hypoxia, and then engages pathways to protect itself from energetic failure that can often lead to cell death in ischemia. You see, our neurons need A steady oxygen supply for ATP production And ways to sense, and then adapt to, a supply disruption. The cell will first increase glycolysis to compensate And starve the mitochondria by shunting pyruvate And increase glucose uptake by increasing its transporters And send out angiogenic and erythropoietic orders. Coordinating such a broad endogenous response Can be effected by one protein that does much at once. Transcription factors are such beasts. They bind to DNA upstream of many target genes, then subtly shape the way transcriptional machinery's recruited to start sites. Then transcripts are exported and translated to peptides, so functional proteins can do the work that must be done to maintain homeostasis and promote survival, hon'. So what transcription factor senses drops in oxygen? And how's it do it? Who can stop it? Where, and why, and when? Hypoxic cells can rapidly induce a protein named Hypoxia inducible factor, 1 alpha, famed For binding to hypoxic response elements nearby to EPO, VEGF, enolase, the list goes on, oh my It's not induced by being synthesized at higher rates Instead, O2-dependent degradation dissipates. Prolyl hydroxylase enzymes ...
  • Autophagy Suite: Atg9 Cycling in the Cytoplasm to Vacuole Targeting Pathway Autophagy is a lysosome-dependent mechanism of intracellular degradation used for the turnover of damaged proteins and excess or aberrant organelles. Various pathways and processes involving macromolecular interactions and assemblies have been disclosed and it continues to gather increasing attention because of the connection to various diseases, development and aging. We have initiated the project to present these processes, and this is the first piece published in the journal, Autophagy, vol. 6, 679-685 (2010).
  • Autophagy Protects against Sindbis Virus Infection of the Central Nervous System Engulfment of Sindbis virus capsids (red, arrowheads) by mouse embryonic fibroblast autophagic membranes (green). Time-lapse microscopy for 1 hr. (Anthony Orvedahl, Sarah MacPherson, Rhea Sumpter, Zsolt Tallóczy, Zhongju Zou, Beth Levine)
  • Zinc(II) ion mediates tamoxifen-induced autophagy and cell death in MCF-7 breast cancer cell line From the Springer article: Zinc(II) ion mediates tamoxifen-induced autophagy and cell death in MCF-7 breast cancer cell line by: Hwang, Jung Jin; Kim, Ha Na; Kim, Jean; Cho, Dong-Hyung; Kim, Mi Joung; Kim, Yong-Sook; Kim, Yunha; Park, Sung-Jin; Koh, Jae-Young; Live cell confocal microscopic images (2 minutes/frame) of MCF-7 cells transfected with LC3-GFP, 60-90 minutes after addition of 17 μM tamoxifen in HBSS. Images were obtained from z-series collections (35 z-section images of 1 μm thickness). (AVI 464 kb) Journal: BioMetals Vol. 23 Issue 6 DOI: 10.1007/s10534-010-9346-9 Published: 2010-11-08
  • Cancer cells in 3D cell culture (breast adenocarcinoma) See more in: "Cell death and lumen formation in spheroids of MCF-7 cells" - Cell Biology International (2009), doi:10.1042/CBI20090024 Jonatas Bussador do Amaral
  • Lysosomes- a highgate school production basically i did this for bio, and got loads of randomers to do different bits... but you're probably in this if you're watching it.
  • The Reverse Warburg Effect Dr. Michael P. Lisanti describes the significance of a new model for cancer. This new model reverses 85 years of research on cancer metabolism, and will allow cancer researchers to design better diagnostics and targeted therapies. This new model is called: The Autophagic Tumor Stroma Model of Cancer or The Reverse Warburg Effect. In this model, cancer cell use "oxidative stress" as a weapon to extract recycled nutrients from normal adjacent cells. It explains how cancer cells eat us alive, resulting in cancer cachexia (severe weight loss) and wasting. Autophagy means "self-eating". See the following Open Access publications: These papers were published today, September 1st, 2010.
  • Autophagy, a guardian against neurodegeneration - Part 3 The Fifth SENS conference (2011) David Rubinsztein - University of Cambridge, UK Intracellular protein misfolding/aggregation are features of many currently incurable late-onset neurodegenerative diseases, like Alzheimer's disease, Parkinson's disease and polyglutamine expansion diseases like Huntington's disease (HD) and various spinocerebellar ataxias. The mutations causing many of these diseases confer novel toxic functions on the target proteins. We showed that the autophagy inducer, rapamycin, reduced the levels of mutant huntingtin and attenuated its toxicity in cells, and in Drosophila and mouse HD models. We have extended the range of intracellular proteinopathy substrates that are cleared by autophagy to other related neurodegenerative disease targets and have provided proof-of-principle in cells, Drosophila and mice. In order to induce autophagy long-term, we have been striving to identify safer alternatives to the mTOR inhibitor, rapamycin. To this end, we have been trying to discover novel components of the autophagy machinery and new signalling pathways and drugs that impact on autophagy. While autophagy induction is protective in models of various neurodegenerative diseases, certain other conditions, including lysosomal storage disorders, are associated with compromised autophagy. I will review these data and then describe how impaired autophagy compromises cellular processes, including the ubiquitin-proteasome system.
  • 6# Wumpscut - Autophagy day
  • Zinc(II) ion mediates tamoxifen-induced autophagy and cell death in MCF-7 breast cancer cell line From the Springer article: Zinc(II) ion mediates tamoxifen-induced autophagy and cell death in MCF-7 breast cancer cell line by: Hwang, Jung Jin; Kim, Ha Na; Kim, Jean; Cho, Dong-Hyung; Kim, Mi Joung; Kim, Yong-Sook; Kim, Yunha; Park, Sung-Jin; Koh, Jae-Young; Live cell confocal microscopic images (2 minutes/frame) of a MCF-7 cell stained with FluoZin-3. Cells were treated with 17 μM tamoxifen and images were obtained from z-series collection (38 z-section images of 1 μm thickness) for 86 minutes. (AVI 170 kb) Journal: BioMetals Vol. 23 Issue 6 DOI: 10.1007/s10534-010-9346-9 Published: 2010-11-08
  • LIFE SCIENCES | Methods in Enzymology (1) A Short History Methods in Enzymology (MIE) is one of the most highly respected publications in the field of biochemistry. In this short video, editors John Abelson and Mel Simon talk about the history of MIE, highlight past volumes, and give you insight into what you can expect from forthcoming volumes.
  • A Diacylglycerol-Dependent Signaling Pathway Contributes to Regulation of Antibacterial Autophagy Live cell imaging to visualize the recruitment of the diacylglycerol (DAG) probe (green) to individual salmonella containing vacuoles (SCVs, blue) which precedes autophagy protein LC3 (red). (Shahab Shahnazari, Wei-Lien Yen, Cheryl L. Birmingham, Jessica Shiu, Anton Namolovan, Yiyu T. Zheng, Keiko Nakayama, Daniel J. Klionsky, and John H. Brumell)
  • Life Sciences Institute's Dan Klionsky Why use yeast cells in basic research?

Blogs & Forum
blogs and forums about autophagy

  • “Rapamycin inhibits the activity of a protein called mTOR which, among its other functions, inhibits a process called autophagy. inhibiting mTOR, rapamycin promotes autophagy, allowing for the breakdown of unnecessary components of the cell”
    — 2009 December 23 : Target Health Global,

  • “Landes Bioscience Autophagy Forum. Anti-phosphorylated-LC3 (S12) September 29th, 2010. Company: Abgent. Catalog #: AP3301a. Comments: The antibody to LC3 phosphorylated at S12 recognizes rat LC3 as well as LC3 in human cell lines and mouse primary neurons, when used at 1”
    — Click here to go to the Autophagy Forum,

  • “Autophagy”
    — Autophagy,

  • “ALS TDI forum is a free portal that is dedicated to exchange information about ALS, scientific advances in ALS, and treatments for ALS”
    Autophagy - ALS Research & Treatments - ALS Forum,

  • “Aging (Albany NY). 2009 Jun 3;1(6):515-28. Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy. Armour SM, Baur JA, Hsieh SN, Land activity by expression of a dominant-negative mutant or RNA interference is sufficient to disrupt autophagy to a similar extent as resveratrol”
    — Inhibition of mammalian S6 kinase by resveratrol suppresses,

  • “[Archive] Discuss and post questions about Apoptosis, Programmed Cell Death, Necrosis, Autophagy, and other forms of cell death”
    — Apoptosis, Autophagy, and Necrosis Forum [Archive,

  • “The paper reviewed here is Autophagy in Neurodegeneration and Development' by Winslow and Rubinsztein and freely available here. As the title suggests, the authors dis cuss”
    — Medpedia News & ***ysis - Medpedia,

Keywords
related keywords for autophagy

Similar
similar for autophagy